Study of histomorphological spectrum of ovarian neoplasms: an institutional perspective


  • Swarnalatha P. Department of Pathology, ACSR Government Medical College, Nellore, Andhra Pradesh, India
  • Rajasekhar Reddy S. Department of Pathology, ACSR Government Medical College, Nellore, Andhra Pradesh, India
  • Chaitanya B. Department of Pathology, RDT Hospitals, Bathalapalli, Anantapuramu, Andhra Pradesh, India



Benign, Histopathology, Malignant, Ovarian neoplasms


Background: Ovarian tumours account for one of the top five gynaecological malignancies in Indian women. The prime objective of the current study is to document the frequency, age distribution and diverse histomorphological spectrum of ovarian tumours in a peripheral institute in South India catering rural population.

Methods: The study comprises of retrospective clinico pathological evaluation of 77 cases of ovarian neoplasms in Indian Red Cross Cancer Hospital, Nellore, India during a 4 year period ( January 2015 to December 2018 ). Non neoplastic ovarian lesions were excluded. Gross and microscopic histopathological examination was done for ovarian neoplasms. These were classified according to the WHO classification of ovarian tumours (2003).

Results: Out of 77 cases studied, majority were malignant  tumours (72.72%), followed by benign (23.38%) and borderline tumours (3.9%). Age ranged from 11-80 years. Epithelial tumours were the most common (75.32%), followed by sex cord stromal tumours (12.98%), germ cell tumours (9.09%) and metastatic ovarian tumours (1.3%). Serous cystadenoma was the commonest benign tumour and serous papillary carcinoma was the commonest malignant ovarian tumour.

Conclusions: It is concluded from this study that on morphological grounds, tumours originating from surface epithelium are the most common. Higher incidence of malignant tumours supports the metaphor often used for ovarian malignancy “ the silent killer ”.


Kaku T, Ogawa S, Kawano Y, Ohishi Y, Kobayashi H, Hirakawa T, et al. Histological Classification of Ovarian Cancer. Med Electron Microsc. 2003;36(1):9-17.

Kitchener HC. Gynaecological cancer. Postgraduate Medical J.1999;75:332-8.

Ernst Lengyel. Ovarian Cancer Development and Metastasis. Am J Pathol. 2010;177(3):1053-64.

Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A. Asian Pacific J Cancer Prev. 2009;10(6):1025-30.

Tortolero L, Mictchell FM, Rhodes HE. Epidemiology and screening of ovarian cancer. Obstet Gynecol Clin North Am. 1994;21(1):1-23.

Sheikh S, Bashir H, Farooq S, Beigh A, Manzoor F, Reshi R. Int J Res Med Sci. 2017 May;5(5):2110-4.

Basic E, Kozaric H, Kozaric M, Suko A. Ovarian-cancer incidence and surgical approach to treatment at clinic for Gynecology and Obstetrics of Clinical Center of University of Sarajevo in 2009.Mater Sociomed, 2010;22:101-4.

Jha R, Karki S. Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J. 2008;10(2):81-5.

Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res. 2015;6(2):107-11.

Thakkar N, Shah S. Histopathological Study of Ovarian Lesions. Int J Science and Research, 2015;4(10):1745-9.

Misra RK, Sharma SP, Gupta U, Gaur R, Misra SD. Pattern of ovarian neoplasm in eastern U.P. J obstetr Gynaecol, 1990; 41(2):242-6.

Kanthikar SN, Dravid NV, Deore PN, Nikumbh DB, Suryawanshi KH. Clinico-histopathological analysis of neoplastic and non-neoplastic lesions of the ovary: a 3-year prospective study in Dhule, North Maharashtra, India. J Clin Diagn Res. 2014;8(8):FC04-7.

Pachori G, Meena US, Sunaria RK, Pachori P, Jethani N, Bayla T, et al. Histopathological study of ovarian tumors in Ajmer region. Int J Med Sci Public Health. 2016;5(7): 1400-3.

Pilli G, Sunita KP, Dhaded AV. Ovarian tumours: A study of 282 cases. J Indian Med Assoc. 2002; 100(7):1-6.

Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumors and tumor-like lesions. Indian J Pathol Microbiol. 2007;50(3):525-7.

Shah S, Hishikar VA. Incidence and management of ovarian tumours. Bombay Hospital J. 2008;50(1):30-3.

Thanikasalam K, Ho CM, Adeed N, Shahidan MN, Azizah WK. Pattern of ovarian tumours among Malaysian women at general hospital, Kuala Lumpur. Med J Malaysia. 1992;47(2):139-46.






Original Research Articles