Correlation between vitamin D and carotid artery intima media thickness in patients with ischemic stroke

Authors

  • Richa Giri Department of Medicine, GSVM Medical College, Kanpur, India
  • Rohit Rai Department of Medicine, GSVM Medical College, Kanpur, India
  • Shivendra Verma Department of Medicine, GSVM Medical College, Kanpur, India
  • Rajendra Kumar Verma Department of Medicine, GSVM Medical College, Kanpur, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20161099

Keywords:

Vitamin D, Cerebral infarction, Carotid intima-media thickness

Abstract

Background: This study aimed to investigate the relationship between serum vitamin D level and carotid artery intima-media thickness in ischemic stroke patients. The correlation of vitamin D and carotid artery intima media thickness in ischemic stroke patients had conflicting results in different parts of the world.

Methods: 217 patients with CVA infarct were selected for analysis between ages 45 and 80 years admitted at our hospital from January 2014 to December 2015. Measurements of serum vitamin D concentration and Carotid-IMT were made by electrochemiluminescence immunoassay and B-mode ultrasound, respectively. Confounding variables like diabetes, hypertension, smoking, alcohol, tobacco, dyslipidemia, BMI, CRP, Serum uric acid, duration of sunlight exposure, prior history of drug intake or fracture and Serum calcium were considered. 200 age and sex matched controls were taken. Questionnaires were used for data collection and multiple linear regression analysis and correlation analysis were used.

Results: The mean serum level of vitamin D was 19.14±9.45 SD ng/mL and  average IMT was 0.78±0.09 SD mm with pearson coefficient of (-0.36) significant at 0.01 level. The R2 value was 0.13.

Conclusions: Correlation analysis found an inverse relationship between serum vitamin D level and carotid-IMT in ischemic stroke patients.

References

Allison M, His S, Wassel C, Morgan C, Joachim H, Wright C, et al. Calcified atherosclerosis in different vascular beds and the risk of mortality. Arterioscler Thromb Vasc Biol. 2012;32:140-6.

Jashari F, Ibrahimi P, Nicoll R, Bajraktari G, Wester P, Henein MY. Coronary and carotid atherosclerosis: similarities and differences. Atherosclerosis. 2013;227:193-200.

Touboul PJ, Grobbee DE, Ruijter HD. Assessment of subclinical atherosclerosis by carotid intima media thickness: technical issues. European Journal of Preventive Cardiology. 2012;19(2):8-24.

Spence JD. Technology Insight: ultrasound measurement of carotid plaque-patient management, genetic research, and therapy evaluation. Nat Clin Pract Neuro. 2006;2(11):611-9.

Kamycheva E, Johnsen SH, Wilsgaard T, Jorde R, Mathiesen EB. Evaluation of Serum 25-Hydroxyvitamin D as a predictor of carotid intima-media thickness and carotid total plaque area in non-smoker: The tromsø study. Int J Endocrinol. 2013;305141.

Carrelli AL, Walker MD, Lowe H, McMahon DJ, Rundek T, Sacco RL, Silverberg SJ, et al. Vitamin D deficiency is associated with subclinical carotid atherosclerosis: the Northern Manhattan Study. Stroke. 2011;42(8):2240-5.

Zitterman A. Vitamin D in preventive medicine: are we ingoring the evidence? Br J Nutr. 2003;89:552-72.

Kamycheva E, Jorde R, Figenschau Y, Haug E. Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity. J Endocrinol Invest. 2007;30(2):126-32.

Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503-11.

Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752-8.

Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci. 2009;338(1):40-4.

Singh AS, Atam V, Patel ML, Chaudhary SC, Sawlani KK, Das L. Carotid intima media thickness as a reflection of generalized atherosclerosis is related to body mass index in ischemic stroke patients. N Am J Med Sci. 2013;5(3):228-34.

Deleskog A, Piksasova O, Silveira A, Gertow K, Baldassarre D, Veglia F, et al. Serum 25-hydroxyvitamin concentration in subclinical carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2013;33(11):2633-8.

Food and Nutrition Board. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington DC. National Academy Press; 2010.

Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N et al. Mannheim Carotid Intima-Media Thickness Consensus (2004-2006-2011). Cerebrovasc Dis. 2007;23:75-80.

Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol. 2010;121(1-2):297-300.

Verdoia M, Schaffer A, Sartori C, Barbieri L, Cassetti E, Marino P et al. Vitamin D deficiency is independently associated with the extent of coronary artery disease. Eur J Clin Invest. 2014;44:634-42.

Freitas D, Alves A, Pereira A, Pereira T. Increased intima-media thickness is independently associated with ischemic stroke. Arq Bras Cardiol. 2012;98(6):497-504.

Zittermann A, Schleithoff SS, Koerfer R. Vitamin D and vascular calcification. Curr Opin Lipidol. 2007;18(1):41-6.

Hsu JJ, Tintut Y, Demer LL. Vitamin D and osteogenic differentiation in the artery wall. Clin J Am Soc Nephrol. 2008;3:1542-7.

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Published

2017-01-02

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Original Research Articles