Peripheral neuropathy in Chronic Kidney Diseases: prevalence and its correlates


  • Gajanan Gondhali Department of Medicine, MIMSR Medical College and YCRH, Latur, Maharashtra, India
  • Ashish Kundalwal Department of Medicine, MIMSR Medical College and YCRH, Latur, Maharashtra, India
  • Anant A. Takalkar Department of Community Medicine, MIMSR Medical College and YCRH, Latur, Maharashtra, India



Chronic kidney diseases, Haemodialysis, Peripheral neuropathy, Prevalence


Background: Peripheral polyneuropathy is most common Chronic Kidney Diseases (CKD) related complication with prevalence of more than 60%. The prevalence of peripheral neuropathy is directly proportional to duration and severity of CKD. Objective of the study was to study and assess the prevalence of peripheral neuritis and its correlates in patients with chronic kidney diseases.

Methods: The present study was a cross sectional; descriptive study was conducted in October 2016 to October 2018. Data analysed by using SPSS 23.0 version.

Results: Out of 90 subjects, majority were from 45-54 years age group (26). 70% were male and 30% were females. Out of 60 pre-HD patients, 33(55%) showed peripheral neuropathy. Out of 30 HD patients, 24(80%) showed peripheral neuropathy. Maximum percentage of PN seen in 45-54 age group (76.92%) amongst the 60 males 39 (65%) and amongst 30 females 18(60%) showed peripheral neuropathy. Maximum percentage of PN seen in >5 years age group (79.31%). Pure axonal sensory motor neuropathy (28.88%) was most common pattern.

Conclusions: Peripheral neuropathy is very common in CKD, more common in dialysis patients as compared to predialysis patients.


Bargman JM, Skoreski K. Chronic kidney disease. In: Kasper DL, Hauser SL, Jamson JL, Fauci AS, Longo DL, Loscalzo J. 19th edition. Harrison’s principle of internal medicine. McGraw-Hill publication; 2018: 1811-1821.

Neuen BL, Chadban SJ, Demaio AR, Johnson DW, Perkovic V. Chronic kidney disease and the global NCDs agenda. BMJ Global Health. 2017;2(2):380.

Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, et al. Global prevalence of chronic kidney disease-a systematic review and meta-analysis. PloS One. 2016 Jul 6;11(7):e0158765.

Singh AK, Farag YM, Mittal BV, Subramanian KK, Reddy SR, Acharya VN, et al. Epidemiology and risk factors of chronic kidney disease in India–results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC Nephrol. 2013 Dec;14(1):114.

Modi GK, Jha V. The incidence of end-stage renal disease in India: a population-based study. Kidney Int. 2006 Dec 2;70(12):2131-3.

Levin A, Stevens PE, Bilous RW, Coresh J, De Francisco AL, De Jong PE, et al. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Supp. 2013 Jan 1;3(1):1-50.

Snyder S, Pendergraph BE. Detection and evaluation of chronic kidney disease. Interventions. 2005;100(1):24-5.

Kaveeshwar SA, Cornwall J. The current state of diabetes mellitus in India. Australas Med J. 2014;7(1):45-8.

Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et al. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertension. 2014 Jun;32(6):1170.

Rajapurkar MM, John GT, Kirpalani AL, Abraham G, Agarwal SK, Almeida AF, et al. What do we know about chronic kidney disease in India: first report of the Indian CKD registry. BMC Nephrol. 2012 Dec;13(1):10.

Sultan LI. Evaluation of the clinical and neurophysiologic parameters of peripheral nerve functions in uremic Egyptian patients. Egypt. J Neurol Psychiat Neurosurg. 2007;44:473-87.

Jasti DB, Mallipeddi S, Anumolu A, Vengamma B, Sivakumar V, Kolli S. A clinical and electrophysiological study of peripheral neuropathies in predialysis and dialysis patients: our experience from south india. J Assoc Phys India. June 2018;66:31.

Deniz E, Aynur O, Gültekin G, Mehmet H, Bahar T, Ahmet K, et al. Clinical and electrophysiological correlation of patients with chronic renal failure: the contribution of quantitative neurological scores. Int J Med Med Sci. 2012;4:192-9.

Alagesan S, Mohan AP. A study on peripheral nerve dysfunction in chronic kidney disease. IOSR J Dental Med Sci. 2016;15(5):22-6.

Ogura T, Makinodan A, Kubo T, Hayashida T, Hirasawa Y. Electrophysiological course of uraemic neuropathy in haemodialysis patients. Postgradu Med J. 2001 Jul 1;77(909):451-4.

Janda K, Stompór T, Gryz E, Szczudlik A, Drozdz M, Kraśniak A, et al. Evaluation of polyneuropathy severity in chronic renal failure patients on continuous ambulatory peritoneal dialysis or on maintenance hemodialysis. Przeglad lekarski. 2007;64(6):423-30.

Aggarwal HK, Sood S, Jain D, Kaverappa V, Yadav S. Evaluation of spectrum of peripheral neuropathy in predialysis patients with chronic kidney disease. Renal Failure. 2013 Nov 1;35(10):1323-9.






Original Research Articles