An unusual cause of short stature-Laron syndrome


  • Alpana K. Somale Department of Paediatrics, TN Medical College, Mumbai, India
  • Maaz Ahmed Department of Paediatrics, TN Medical College, Mumbai, India



Growth hormone, Growth hormone receptor, Growth hormone receptor insensitivity, Laron syndrome


Laron syndrome is an autosomal recessive disorder characterized by an insensitivity to growth hormone (GH), caused by a variant of the growth hormone receptor. 15 month old, male child, born of third degree consanguineous marriage presented with short stature (57 cm, below the 3rd centile) with normal head size, mild developmental delay, undescended testis and micropenis. Normal thyroid profile, serum cortisol was normal and bone age of 1 year. MRI brain showed small sized pituitary. Random growth hormone was 21.4 ng/ml (normal more than 10 ng/ml), IGF-1 level less than 25 ( normal: upto70  micro/L), IGF-1 generation test with pre-test IGF-1 levels less than 25 and post-test less than 25 which was suggestive of resistance to growth hormone or growth hormone insensitivity that is Laron dwarfism. Parents were counselled about the possible outcome and prognosis. In conclusion for the diagnosis of growth hormone insensitivity a high index of suspicion and the important functional test is insulin-like growth factor 1 generation test. Currently only treatment is daily administration of insulin-like growth factor-1from early childhood.


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