Study of clinical and laboratory profile of dengue fever in a tertiary care hospital


  • Sangram S. Mangudkar Department of Medicine, Dr D Y Patil Medical College, Pimpri, Pune, Maharashtra, India
  • Sachin K. Shivnitwar Department of Medicine, Dr D Y Patil Medical College, Pimpri, Pune, Maharashtra, India
  • Atiullah I. Malik Department of Medicine, Dr D Y Patil Medical College, Pimpri, Pune, Maharashtra, India



Bradycardia, Dengue fever, Headache, NS1 antigen, Thrombocytopenia


Background: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence over the last few years with considerable morbidity and mortality. This study was designed to study the clinical and biochemical parameters in dengue fever patients.

Methods: Prospective observational study was undertaken among adult patients in a tertiary care hospital. fifty patients were studied and analysed. All patients who were NS1 (Non-Structural Protein 1) antigen or IgM dengue positive were included in the study. Clinical features, haematological and biochemical parameters were noted.

Results: Of the 50 patients studied, majority were males (68%). Fever was the major symptom (100%) followed by Body ache (84%), Headache (64%), Retro-orbital pain (52%), Myalgia (48%), conjunctival injection (40%), Itching (40%), abdominal pain (36%), Bradycardia (34%), Rash (30%), pleural effusion and ascites both seen in (28%). Significant derangements in platelet (76%), leucocyte counts (84%) and serum transaminases (58%) were noted.

Conclusions: Fever associated with headache, retroorbital pain, erythematous morbilliform rash, conjunctival injection and itching over palms and soles along with thrombocytopenia, leukopenia, elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have little role in management of dengue patients unless patients having active bleeding secondary to thrombocytopenia due to dengue fever.


Suzzane MS. Dengue. Medscape. Available at: Accessed 4 October 2014.

Centers for Disease Control and Prevention (CDC. Imported dengue--United States, 1997 and 1998. MMWR. Morbid Mortal Weekly Rep. 2000 Mar 31;49(12):248.

Engelthaler DM, Fink TM, Levy CE, Leslie MJ. The reemergence of Aedes aegypti in Arizona. Emerg Infec Dis. 1997 Apr;3(2):241.

Kyle JL, Harris E. Global spread and persistence of dengue. Annu Rev Microbiol. 2008 Oct 13;62:71-92.

Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998 Jul 1;11(3):480-96.

Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, Endy TP, et al. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infe Dis. 2010 Apr 15;50(8):1135-43.

Mandal SK, Ganguly J, Sil K, Chatterjee S, Chatterjee K, Sarkar P, et al. Clinical profiles of dengue fever in a teaching hospital of eastern India. Headache. 2013;40:62-16.

Munde DD, Shetkar UB. Clinical features and haematological profile of dengue fever. Ind J Appl Res. 2013 Jan;3(1):131-2.

Rajamohanan RD, Philip AZ. A Study of Clinical Profile of Dengue Fever in Kollam, Kerala, India. Dengue Bull. 2005;29:197-202.

Muniraja PK, Swapna M, Mashyastha R. Clinical Manifestations and Bio-Chemical profile of dengue fever in a tertiary care Centre. Inter J Clin Cases Invest. 2013;5:72-82.

Nadia A, Malik M, Jamil A, Jahangir M, Tirmiz N, Majid A, et al. Cutaneous manifestations in patients of dengue fever. J Pak Assoc Dermatol. 2012;22:320-24.

Ahmed S, Ali N, Ashraf S, Ilyas M, Tariq WU, Chotani RA. Dengue fever outbreak: a clinical management experience. J Coll Phys Surg Pak. 2008 Jan 1;18(1):8-12.

Kularatne SA, Gawarammana IB, Kumarasiri PR. Epidemiology, clinical features, laboratory investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka. Southeast Asian J Trop Med Pub Health. 2005 May 1;36(3):686.






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