Pattern of hemoglobinopathies and thalassemia in Manipur, India

Hidangmayum Dwijaraj Sharma, Konsam Biona Devi, Pravin Kumar, Ksh Birendra Singh, Diamond Princy J., Rajesh Boini


Background: Hemoglobinopathies are the commonest genetic disorders worldwide. Thalassemia Major, Thalassemia Intermedia and Sickle Cell Disease are the major disorders that require lifelong management and are to be considered for prevention. In India, Beta-Thalassemia is prevalent across the country, with an average frequency of carriers being 3-4%.

Methods: This is a cross sectional study conducted between June 2016 - May 2017 in the Department of Medicine, RIMS Imphal in 453 patients as a workup for anemia and clinically suspected cases of Hemoglobinopathy or beta thalassemia. Blood samples were collected and sent for Haemoglobin Electrophoresis using cellulose alkaline technique.

Results: Among the 453 cases of the population surveyed, 35% showed the presence of abnormal hemoglobin. 16% were found to be beta thalassemia carrier, 11.69% HbE trait, 6.62% Homozygous HbE, 0.4% beta thalassemia and 0.7% had Hereditary persistence of HbF.

Conclusions: High prevalence of Beta Thalassemia trait occurred more frequently than other Hemoglobinopathies. The study concludes that it is immensely important epidemiologically to explore the haemoglobin variants in Manipur so that the carriers can be detected for prevention of more serious disorder in the future generations.


Beta-Thalassemia, Haemoglobinopathies, Hemoglobin electrophoresis, Hereditary persistence of HbF

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Modell B, Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Org. 2008;86:480-87.

Weatherall D. The inherited disorders of hemoglobin: an increasingly neglected global health burden. Indian J Med Res. 2011;134(4):493-97.

WHO Executive Board. Eb118/5, 118th Session Report by the Secretariat on Thalassaemia and other Haemoglobinopathies: Prevalence of Haemoglobinopathies; 11 May; 2006:1-8.

Balgir RS. The genetic burden of hemoglobinopathies with special reference to community health in India and the challenges ahead. Indian J Hematol Blood Transfus. 2002;20:2-7.

Mohanty D, Colah RB, Gorakshakar AC, Patel RZ, Master DC, Mahanta J, et al. Prevalence of β-thalassemia and other hemoglobinopathies in six cities in India: a multicentre study. J Commu Gene. 2013;4:33-42.

Balgir RS. Genetic epidemiology of the three predominant abnormal hemoglobins in India. J Assoc Physicians India. 1996,44(1):25-8.

Urade BP. Sickle Cell Gene Scenario in tribal India. J Health Med Inform. 2012;3:114.

Patne SC, Shukla J. Hemoglobin E disorders in Eastern Uttar Pradesh. Indian J Pathol Microbiol. 2009;52:110-2.

Haemoglobin electrophoresis: Medlineplus Medical Encyclopedia. Available at: Accessed 09 August 2016.

Bain BJ. Hemoglobinopathy diagnosis. 2nd edition. Black Well Publishing; 2005:201-206.

Singh MR, Choudhury B, Singh TS. Haemoglobin E distribution in four endogamous populations of Manipur (India). Euras J Anthropol. 2010 Dec 29;1(2):109-17.

Das MK, Dey B, Roy M, Mukherjee BN. High prevalence of haemoglobin E in three populations of the Malda district, West Bengal, India. Human Heredity. 1991;41(2):84-8.

Fucharoen S, Winichagoon P. Clinical and hematologic aspects of hemoglobin E beta thalassemia. Haematol. 2000;7(2):106-12.