Assessment of plasma blood sugar level in first degree relatives of known type 2 diabetes patients: a descriptive study from Maharashtra, India
DOI:
https://doi.org/10.18203/2349-3933.ijam20200663Keywords:
First degree relatives, Plasm blood sugar, Type 2 diabetesAbstract
Background: There is steady increase in the prevalence of diabetes mellitus from 0.73% to current 2.4% in rural and 4.0% to 11.6% in urban areas. Familial clustering of diabetes may support a genetic predisposition to diabetes. With increase in the prevalence of diabetes there is increase in number of first degree relative as well, thus an increased risk of developing diabetes, will also increase. To study the plasma glucose levels in First-degree relatives of family member of type 2 diabetic patients was the objective of the present study.
Methods: It is a descriptive observational study with 1020 individuals serially coming to our outpatient Department for Pre-employment Medical Health Check Up Annual Health Check Up were selected. These individuals have been enrolled for the study and their family history of diabetes was noted, their sugar levels and their lipid levels were estimated and their body mass index was calculated. The data thus collected and analyzed with excel.
Results: 184 (18%) individuals were FDRs, were as 836 (82%) individuals were Non-FDRs. There were 754 (74%) males [131(17%) FDR and 623(83%) Non-FDR], were as 213 (26%) females [53(20%) FDR and 213(80%) Non-FDR], 61(6%) individuals were having Diabetic Mother, 91(9%) individuals had Diabetic Father and 32(3%) were those in whom both the Parents were Diabetic. It was found that maternal history has strong association for getting abnormal BSL levels as compared to a diabetic father as the RR of 9.82 (95% 4.84 to 19.95) in individuals with mother being diabetic, and RR of 1.54(95% 0.68 to 3.87) of father being diabetic.
Conclusions: Family history of diabetes, maternal history of diabetes and history of both the parents having diabetes are risk factors for diabetes in FDRs.
References
K Park. Park’s textbook of Preventive and Social Medicine. 19th Ed. India: M/s Banarsidas Bhanot Publisher; 2007:329.
World Health Organization. Fact sheet No. 312 November 2008. Available at: www.who.int. Accessed 25th November 2007.
Kokiwar PR, Gupta S, Durge PM. Prevalence of diabetes in a rural area of central India. Int J Diab Dev Ctries. 2007 Mar;27(1):8-10.
Dube S, Sharma VK, Dubey TN, Mehta A, Gour D. Screening for impaired fasting glucose and diabetes mellitus among people with major risk factors for type 2 diabetes mellitus. Inter J Diab Develop Countries. 2007 Jun 1;27(2):35-40.
Jali MV, Kambar S. Prevalence of diabetes amongst the family members of known diabetics. Int J Diab Dev Ctries. 2006 Jun;26(2):81-5.
van Dam RM, Boer JM, Feskens EJ, Seidell JC. Parental history of diabetes modifies the association between abdominal adiposity and hyperglycemia. Diab Care. 2001 Aug 1;24(8):1454-9.
Mykkänen L, Laakso M, Uusitupa M, Pyörälä K. Prevalence of Diabetes and Impaired Glucose Tolerance in Elderly Subjects and Their Association With Obesity and Family History of Diabete. Diab Care. 1990 Nov 1;13(11):1099-105.
Deo SS, Zantye A, Mokal R, Mithbawkar S, Rane S, Thakur K. To identify the risk factors for high prevalence of diabetes and impaired glucose tolerance in Indian rural population. Inter J Diab Develop Countries. 2006 Jan 1;26(1).
Janghorbani M, Amini M, Willett WC, Gouya MM, Delavari A, Alikhani S. First nationwide survey of prevalence of overweight, underweight, and abdominal obesity in Iranian adults. Obesity. 2007 Nov;15(11):2797-808.
Rodrigues TD, Canani LH. Family history of type 2 diabetes is associated with metabolic syndrome in obese female subjects. Revista HCPA. Porto Alegre. 2008;28(2):81-4.
Kumar A, Tewari P, Sahoo SS, Srivastava AK. Prevalence of insulin resistance in first degree relatives of type-2 diabetes mellitus patients: A prospective study in north Indian population. Ind J Clini Biochem. 2005;20(2):10-7.
Bjørnholt JV, Erikssen G, Liestøl K, Jervell J, Thaulow E, Erikssen J. Type 2 diabetes and maternal family history: an impact beyond slow glucose removal rate and fasting hyperglycemia in low-risk individuals? Results from 22.5 years of follow-up of healthy nondiabetic men. Diab Care. 2000 Sep 1;23(9):1255-9.
