A cross sectional study of lipid profile in stroke patients

Authors

  • Nirmala A. C. Department of Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
  • Hrishikesh S. Department of Internal Medicine, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20201124

Keywords:

Anti-rabies vaccine, Dog bite, Rabies

Abstract

Background: Atherosclerosis affects multiple vascular beds, accounting for nearly all of coronary heart disease and some proportion of ischemic strokes. Serum lipid levels have an effect on the short-term mortality due to strokes. But in some studies, there was no dyslipidemia in patients who presented with acute stroke. It is important to evaluate the serum lipid levels in both the types of strokes to guide lipid lowering therapy which can reduce incidence of stroke and related mortality. This study is undertaken to evaluate the role of serum lipids in patients of stroke in our centre.

Methods: It is a cross sectional study, conducted on 176 patients of stroke, who were assessed by NIHSS stroke scale clinically. Serum lipid profile was measured in all patients. Data was entered in Microsoft Excel and analysed by descriptive statistics. Chi Square test was used for association of qualitative variables. A p value<0.05 was considered statistically significant.

Results: In this study conducted on 176 patients, LDL values were deranged more in CVA-bleed group compared to CVA-infarct group. BMI was the best anthropometric measure that correlated with LDL. LDL was also the most common parameter that was deranged in nonsmokers (61.8%) whereas in smokers, total cholesterol (66.3%) was most commonly deranged. Triglyceride and VLDL values were deranged more commonly in diabetic group than in non-diabetic group.  A total of 123 out of 145patinets with CVA- infarct, had deranged lipid profile and among patients with CVA- bleed 24 out of 32 had deranged lipid profile.

Conclusions: Results of this study shows significant derangement in lipid profile especially in LDL cholesterol levels in both infarct and bleed group, therefore starting statin therapy would prove to be beneficial in preventing recurrence of stroke.

References

World Health Organization. The world health report 2002: reducing risks, promoting healthy life. World Health Organization; 2002.

Egovindarajulu K, Maaran AT, Prathiba P, Saiprashanth PR. A study on Prognostic Significance of Serum Ferritin in Patients with Acute Ischemic Stroke. IOSR J Dent Med Sci. 2016Oct;15(10):31-9.

Kunitz SC, Gross CR, Heyman A, Kase CS, Mohr JP, Price TR, et al. The pilot Stroke Data Bank: definition, design, and data. Stroke. 1984 Jul;15(4):740-6.

Caplan LR, Hier DB, D'Cruz I. Cerebral embolism in the Michael Reese stroke registry. Stroke. 1983 Jul;14(4):530-6.

Mohr JP, Caplan LR, Melski JW, Goldstein RJ, Duncan GW, Kistler JP, et al. The Harvard cooperative stroke registry: a prospective registry. Neurology. 1978 Aug 1;28(8):754-62.

Ballantyne CM, Herd JA, Ferlic LL, Dunn JK, Farmer JA, Jones PH, et al. Influence of low HDL on progression of coronary artery disease and response to fluvastatin therapy. Circulation. 1999 Feb 16;99(6):736-43.

Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 1989 Jan;79(1):8-15.

Miller GJ, Miller NE. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975 Jan 4;305(7897):16-9.

Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med. 1991 Aug 8;325(6):373-81.

Yaari S, Even-Zohar S, Goldbourt U, Neufeld H. Associations of serum high density lipoprotein and total cholesterol with total, cardiovascular, and cancer mortality in a 7-year prospective study of 10 000 men. Lancet. 1981 May 9;317(8228):1011-5.

National Cholesterol Education Program (US). Expert Panel on Detection, Treatment of High Blood Cholesterol in Adults. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health; 2002. JAMA. 2002;285(19):2486-97.

Elnasri HA, Ahmed AM. Patterns of lipid changes among type 2 diabetes patients in Sudan. EMHJ-East Mediter Health J. 14 (2):314-24.

Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nature Rev Endocrinol. 2009 Mar;5(3):150-9.

Smith S, Lall AM. A Study on lipid profile levels of diabetics and non-diabetics among Naini region of Allahabad, India. Turk J Biochem. 2008;33(4):138-41.

Howard BV. Lipoprotein metabolism in diabetes mellitus. J Lipid Res. 1987;28(6):613-28.

Taskinen MR, Kahri J, Koivisto V, Shepherd J, Packard J. Metabolism of HDL apolipoprotein A-I and A-II in type 1 (insulin-dependent) diabetes mellitus. Diabetol. 1992;35(4):347-56.

Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37(4):693-707.

Singh D. Effect of cigarette smoking on serum lipid profile in male population of Udaipur (Rajasthan). Int J Clin Biochem Res. 2016;3(4):368-70.

Willey JZ, Xu Q, Boden-Albala B, Paik MC, Moon YP, Sacco RL, et al. Lipid profile components and risk of ischemic stroke: the Northern Manhattan Study (NOMAS). Arch Neurol. 2009 Nov 9;66(11):1400-6.

Shahar E, Chambless LE, Rosamond WD, Boland LL, Ballantyne CM, McGovern PG, Sharrett AR. Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke. 2003 Mar 1;34(3):623-31.

Shenoi AS, Kadam V, Ghanekar J. Effect of smoking on serum lipid levels: а hospital-based study. MGM J Med Sci. 2015;2(1):13-5.

Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis. 2014;13(1).

Manjareeka M, Nanda S, Mishra J. Correlation between anthropometry and lipid profile in healthy subjects of Eastern India. J Mid-life Health. 2015;6(4):164.

Downloads

Published

2020-03-21

Issue

Section

Original Research Articles