Hyperuricemia among hypertensive and normotensive individuals: a case control study
Keywords:Hyperuricemia, Hypertension, Normotensive individuals, Serum uric acid
Background: The depth of association between hypertension and serum uric acid remains a mystery. In order to know the exact association between hypertension and serum uric acid, authors intended to investigate the serum uric acid levels among hypertensive and non-hypertensive patients and, authors assessed whether hyperuricemia increases with increasing duration of hypertension and severity of hypertension.
Methods: This case control study was conducted among hypertensive (Cases) and non-hypertensive patients (Controls) attending outpatient and inpatient department of general medicine in Sri Muthukumaran Medical College and Research Institute during January 2019 to March 2019. A total of hundred patients were included in this study with fifty cases and control each. Data was conducted using a proforma, covering particulars related to hypertension and the levels of serum uric acid were also noted in the same. Data analysis was done using SPSS.
Results: Hyperuricemia among cases and control was found to be statistically significant association with odds ratio of 3.7. Also, the study showed that the serum uric acid levels were significantly increased in patients with Stage 2 hypertension compared to stage 1 hypertension. Also, cases with longer duration of hypertension had significantly raised serum uric acid levels compared to cases with lesser duration of hypertension.
Conclusion: Assessment of serum uric acid may be recommended for all the hypertensive cases.
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2224-60.
Mahomed F. The Etiology of Bright’s disease and the prealbuminuric state. Med Chir Trans. 1874;39:197-228.
Haig A. Uric Acid as a Factor in the Causation of Disease. 4th edn London, UK: J & A Churchill; 1897.
Huchard H. Arteriolosclerosis: including its cardiac form. JAMA. 1909;53:1129.
Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131:7-13.
Gutierrez-Macias A, Lizarralde-Palacios E, Martinez-Odriozola P, Miguel-De-La-Villa F. Fatal allopurinol hypersensitivity syndrome after treatment of asymptomatic hyperuricemia. Br Med J. 2005;331:623-4.
Kinskey D, Walther R, Wise HS, Smithwick R. Incidence of hyperuricemia in 400 hypertensive patients. Circulation, 1961,24(4):972.
Kolbel F, Gregorova I, Souka J. Serum uric acid in hypertensives. Lancet. 1965;1;519.
Breckenridge. Hypertension and Hyperuricemia. The Lancet. 1966;287:316-9.
Bulpitt CJ. Serum Uric Acid in hypertensive patients. Britis Hear J. 1975:37;1210-5.
Ramsay L. Hyperuricemia in hypertension, role of alcohol. Britis Med J. 1979:1;653-4.
Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG. Serum Uric Acid in Essential Hypertension: an indicator of renal vascular involvement. Annul Int Med. 1980;93:817-21.
Turak O, Özcan F, Tok D, İşleyen A, Sökmen E, Taşoğlu I, et al. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hyper. 2013 Jan;15(1):7-13.
Tykarski A. Evaluation of renal handling of uric acid in essential hypertension; hyperuricemia related to decreased urate secretion. Nephrol. 1991;59(3);364-8.
Goldstein HS, Manowitz P. Relation between serum uric acid and blood pressure in adolescents. Annul Hum Biol. 1993;20(5):423-31.
Fessel WJ. Renal outcomes of gout and hyperuricemia. Am J Med. 1979;67(1):74-82.
Cannon PJ, Stason WB, Demartini FE, Sommers SC, Laragh JH. Hyperuricemia in primary and renal hypertension. New England J Med. 1966 Sep 1;275(9):457-64.