DOI: http://dx.doi.org/10.18203/2349-3933.ijam20200508

A retrospective study of clinical profile and outcome of patients with rodenticide poisoning in tertiary care teaching hospital, Mandya, Karnataka, India

Rajashekar S., Prakash G. M.

Abstract


Background: Poisoning is the major health problem in developing countries like India. Rodenticides are one of the commonest substances used for poisoning in India. Rodenticides are the substances used to kill rats. They differs from chemical composition and toxicity profile. Prognosis mainly depends on chemical content of poison.

Methods: This retrospective record-based study was conducted between October 2018 to September 2019 at MIMS tertiary care teaching hospital, Mandya, Karnataka, India. Data regarding age, sex, marital status, occupation, socioeconomic status, type of poison, route of exposure, clinical presentation, complications and outcome of poisoning and associated comorbid conditions were collected from the hospital records and documented in the pre-structured proforma. Descriptive analysis was carried out by the mean and standard deviation for quantitative variables, frequency and proportion for categorical variables.

Results: Out of 126 study subjects, 77 (61.11%) were female, 49 (38.89%) were male. Most common age group was 21 to 30 years (45.23%), followed by 31 to 40 years (26.19%) group. Most common poison was zinc phosphide (52.39%), followed by yellow phosphorous (30.16%). Mode of poisoning was suicidal (94.4%) followed by accidental (5.6%).Most common symptom at presentation was nausea, vomiting (62.6%) followed by pain abdomen (52.4%).Most common complication was hepatitis 34 (26.98%) patients, followed by hepatic encephalopathy in 6 (4.76%) and cardiogenic shock in 6 (4.76%) patients. Total mortality was 8 (6.3%).

Conclusions: Among rodenticides zinc phosphide was most common consumed poison in present study. Yellow phosphorous was most toxic poison and Aluminium phosphide was most lethal poison. Even though there is no specific antidote, early symptomatic treatment is the key in reducing the mortality.


Keywords


Aluminium phosphide, Rodenticide, Yellow phosphorous, Zinc phosphide

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References


Kanchan T, Menezes RG. Suicidal poisoning in southern India: gender differences. J Forensic Leg Med. 2008;15(1):7-14.

WHO. environmental health criteria No.73 - phosphine and selected metal phosphide; International program on chemical safety, World Health Organization: Geneva, Switzerland; 1988.

Gargi J, Thejpal HR, Chalana A, Rai G, Choudhary R. A retrospective autopsy study of poisoning in the northern region of Punjab. J Punjab Acad Forens Med Toxicol. 2008;8(2):17-9.

Shashidhara KC, Marijayanth M, Reddy PK, Kaluvakuri S. Clinical profile and outcome of rodenticide poisoning in patients admitted to a tertiary care teaching hospital in Mysore, Karnataka, India. Int J Res Med Sci. 2016;4:5023-7.

Balasubramanian K, Sethuraman VK, Balamurugesan K, Vishwanathan S. A retrospective study of clinical profile and outcome of patients with rodenticide poisoning in a tertiary care hospital. IJAM. 2019;6(2):1-6.

Suneetha DK, Inbanathan J, Kannoth S, Reshma PK, Shashank MS. Profile of Rat Killer Poisoning Cases in a Tertiary Care Hospital at Mysore. Int J Scient study. 2016;3(12):260-3.

Chugh SN, Dushayant K, Ram S, Arora B. Incidence and outcome of aluminium phosphide poisoning in a hospital study. Indian J Med Res. 1991;94:232-5.

Singh B, Unnikrishnan B. A profile of acute poisoning at Mangalore (South India). J Cinic Forensic Med. 2006;13(3):112-6.

Sugunan S, Krishnan R, Kumar KS, Geetha S. Rodenticide poisoning in children: a study of clinical profile and electrocardiographic changes. IJCH. 2017;4(2):136-9.

Khurana P, Dalal JS, Multani AS, Tejpal HR. The study of aluminium phosphide poisoning in a tertiary care hospital, Amritsar. J Indian Acad Foren Med. 2011;33(4):332-6.

Chikkaveraiah Kuppegal S, Marijayanth M, Reddy PK, Kaluvakuri S. Clinical profile and outcome of rodenticide poisoning in patients admitted to a tertiary care teaching hospital in Mysore Karnataka. IJRMS. 2016;4(11):5023-7

Nalaboth M, Monigari N, Acharya R. Clinical profile and outcomes of rodenticide poisoning in tertiary care hospital. Int J Sci Res Pub. 2015;5(8):1- 2.

Kumar S, Elhence GP, Mital HS, Mehrotra VS, Khanna PN. Intravenous magnesium sulphate therapy in aluminium phosphide poisoning. JAPI. 1990;38(1):32.

Siwach SB, Singh P, Ahlawat S, Dua A, Sharma D. Serum and tissue magnesium content in patients of aluminium phosphide poisoning and critical evaluation of high dose magnesium sulphate therapy in reducing mortality. J Assoc Physic India. 1994;42(2):107.