Study of microalbuminuria and its correlation with severity of disease in patients with chronic obstructive pulmonary disease
Keywords:Chronic obstructive pulmonary disease, Gold staging, Microalbuminuria
Background: Microalbuminuria is a marker of endothelial dysfunction and an important risk factor for cardiovascular diseases. Microalbuminuria may be seen due to hypoxemia in patients with chronic obstructive pulmonary disease (COPD). The objectives were to study the presence of microalbuminuria in patients with chronic obstructive pulmonary disease and to determine the relationship of microalbuminuria with severity of COPD using GOLD staging.
Methods: The study was done on 68 patients of COPD. Urine spot albumin measurement, pulmonary function tests, spirometry and GOLD staging were done. Severity of COPD was assessed by GOLD staging. Pearson Co-relation test and ANOVA test were used for statistical analysis.
Results: Statistical analysis showed that strong and statistically significant positive correlation of Microalbuminuria with GOLD staging(r =0.749, p = 0.001).
Conclusions: Microalbuminuria(MAB) was found to increase in patients with increasing severity of COPD. Hence its potential role as a marker of severity of disease and in predicting risk of cardiovascular disease can be explored.
Murray C, Lopez A. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. The Lancet. 1997;349(9064):1498-504.
Mehmood K, Sofi FA. Microalbuminuria and hypoxemia in patients with COPD. J Pulm Respir Med. 2015;5(280):2.
Casanova C, de Torres J, Navarro J, Aguirre-Jaíme A, Toledo P, Cordoba E, et al. Microalbuminuria and Hypoxemia in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2010;182(8):1004-10.
Kumar R. Study of microalbuminuria in patients with stable COPD. Ann Int Med Dent Res. 2016;2:95-8.
Polatli M, Çakir A, Cildag O, Bolaman AZ, Yenisey C, Yenicerioglu Y. Microalbuminuria, von Willebrand factor and fibrinogen levels as markers of the severity in COPD exacerbation. J Thrombo Thrombol. 2008 Oct 1;26(2):97-102.
Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, et al. The body-mass index, air flow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350:1005-12.
Bulcun E, Ekici M, Ekici A, Kisa U. Microalbuminuria in chronicobstructive pulmonary disease. COPD. 2013;10(2):186-92.
Shayo F, Lutale J. Albuminuria in patients with chronic obstructive pulmonary disease: a cross-sectional study in an African patient cohort. BMC Pulm Med. 2018;18(1)125.
Bozkus F, Dikmen N, Samur A. Microalbuminuria in subjects with COPD: relationship to the new version of global initiative for chronic obstructive lung disease staging. Respir Care. 2017 Mar 1;62(3):307-14.
Gupta P, Kumar A, Chaurasia AK, Gupta A. Prevalence and clinical significance of microalbuminuria and hypoxemia in patients with chronic obstructive pulmonary disease. Int J Advan Med. 2019;6(4):1299.