Cystatin C in the early diagnosis of diabetic nephropathy and its correlation with albuminuria

Kunal Gupta; S.B. Nayyar; Jasmine Sachdeva; Prateek Kumar

doi:10.18203/2349-3933.ijam20170020

Authors

Kunal Gupta Department of Medicine, Sri Guru Ram Das Institute of Medicine, Amritsar, Punjab, India
S.B. Nayyar Department of Medicine, Sri Guru Ram Das Institute of Medicine, Amritsar, Punjab, India
Jasmine Sachdeva Department of Medicine, Sri Guru Ram Das Institute of Medicine, Amritsar, Punjab, India
Prateek Kumar Department of Medicine, Sri Guru Ram Das Institute of Medicine, Amritsar, Punjab, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20170020

Keywords:

Albuminuria, Cystatin C, Diabetes Mellitus, Diabetic nephroapthy

Abstract

Background: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycaemia. The metabolic dysregulations associated with DM causes secondary pathophysiological changes in multiple organ systems which result in various complications, responsible for the morbidity and mortality associated with the disease.

Methods: The present study was undertaken in the Department of Medicine in collaboration with the Department of Biochemistry, of SGRDIMSR, Vallah, Sri Amritsar, Punjab, India. The present hospital based study was undertaken with a total number of 100 patients.

Results: The mean Cystatin C values in Group A were 1.73 and mean Cystatin C values in group B were 2.07. The results show that the Cystatin C values were raised even in the patients in whom clinical albuminuria had not yet started.

Conclusions: serum Cystatin C may be considered as an early marker, than microalbuminuria and serum creatinine, the commonly used marker for nephropathy, for declining renal function, in diabetic subjects. Further studies in larger population are needed to confirm this result.

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