A review of role of uric acid in acute ischemic stroke: changing trends


  • Soorya Narayanan Balasubramani Department of Medicine, Mahatma Gandhi Medical College, Sri Balaji Vidyapeeth (deemed to be university), Pondicherry, India
  • Jeyapalan Kuppuswamy Department of Medicine, Mahatma Gandhi Medical College, Sri Balaji Vidyapeeth (deemed to be university), Pondicherry, India




Acute ischemic stroke, Antioxidant, Cerebrovascular accident, Hyperuricemia, Neuro-protective, Uric acid


Uric acid, a powerful and potent antioxidant. Effect of uric acid in acute stroke was a controversy. Chronic hyperuricemia is atherogenic. But in recent days various articles were published about the antioxidant and the beneficial effects of uric acid due to cerebral antioxidant effect. In this article, we had reviewed various articles which discuss the major beneficial and deleterious effect of uric acid in neurological diseases to conclude the effect of uric acid in the scenario of acute ischemic stroke. This review was conducted through an Internet search on a public access website like PubMed, Google Scholar, Cochrane library, ProQuest and Medline databases until 2019. Keywords utilized included uric acid (UA), Acute ischemic stroke, neuroprotection, stroke therapy, and vasculoprotection. Total of 10 article from literature was reviewed, the major exclusion criteria were the studies that included patients which coronary artery disease, chronic kidney disease, Metabolic syndrome and patients who are taking drugs that influencing the uric acid levels. Chronic hyperuricemia is atherogenic and it had a negative impact on outcome in stroke, but in acute setting resent days various papers had been published about the beneficial effect of uric acid due to its antioxidants property. This was further supported by the co administration of Intravenous uric acid along with thrombolysis for acute ischemic stroke. Hence, we had concluded that, uric acid had a beneficial effect in a setting of acute ischemic stroke.


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