A review of relationship between platelet indices and microvascular complications in type 2 diabetic patients


  • Subashini Subramanian Department of Medicine, Mahatma Gandhi Medical College, Sri Balaji Vidyapeeth University (Deemed to be), Pondicherry, India
  • Siva Ranganathan Green Department of Medicine, Mahatma Gandhi Medical College, Sri Balaji Vidyapeeth University (Deemed to be), Pondicherry, India




Diabetes, Microangiopathy, Nephropathy, Neuropathy, Platelet indices, Retinopathy


Diabetes is a common metabolic disorder affecting the world population which accounts for major amount of morbidity and mortality mainly due to its micro vascular and macro vascular complications. This is a comparative study which analyses the correlation between the Platelet indices like Mean platelet volume, platelet distribution width, plateletcrit and total platelet count in diabetic patients with micro vascular complications and without complications. This review of the literature was conducted through an Internet search on a public access website like PubMed Google scholar, Medline databases until 2019. Keywords utilized included Diabetes mellitus, Microvascular complications, platelet indices. The major exclusion criteria was studies which included the patients with macrovascular complications and patients taking drugs which alters the platelet indices. All these articles were analysed. Platelet indices like Mean platelet volume and platelet distribution width was significantly higher in individuals with microvascular complications, predominantly Diabetic Nephropathy and Diabetic Retinopathy when compared to those without microvascular complications. Change in platelet indices were found to be statistically associated with diabetic microvascular complications. Hence these parameters can be used to monitor and to predict the risk of microvascular complications.


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