A study of thyroid dysfunction in patients with type 2 diabetes mellitus at new civil hospital, Surat, Gujarat, India

Kunal D. Kumar, Mahesh G. Solu, Ankit P. Kakadiya, Arpit V. Patel, Sumer S. Ramawat, Vishwakiran .


Background: Thyroid diseases and diabetes mellitus, as comorbid condition these together throw a great burden to medicine and humanity. Considering the ever increasing population of diabetics in our country and the significant causal relationship established by current literature, this study was undertaken.

Methods: A thorough clinical history regarding diabetes mellitus (onset, duration), any history of long-term illness, any previous thyroid dysfunction, previous history of any kind of drug therapy, whether the patient was on insulin or oral hypoglycaemic drugs was sought. All diabetic patients were evaluated for thyroid dysfunction by testing thyroid profile (T3, T4 and TSH).

Results: In the present study, out of the 100 diabetic patients, 18 (18%) patients had thyroid dysfunction and 82 (82%) patients were found to be euthyroid. The prevalence of thyroid dysfunction more in females as compared to males (68.75% vs 31.25%) and highest in the age group of >60 years. The prevalence of thyroid dysfunction found to be more in patients with HbA1C >7 as compared to patients with HbA1C <7. Out of 18 diabetic patients who had thyroid dysfunction, 05 (27.78%) had duration of diabetes >1 - 5 years and 08 (44.44%) had duration of diabetes 6 - 10 years. The prevalence of thyroid dysfunction found to be more in patients who had BMI >30 and patients who were on both oral hypoglycaemic agents and insulin.

Conclusions: There is a high prevalence of thyroid disorders in patients of type 2 diabetes mellitus which found to be more in Females, Elderly patients, Patients with uncontrolled diabetes and BMI > 30.


Body mass index, Duration of diabetes, HbA1c, Thyroid dysfunction, Type 2 diabetes mellitus

Full Text:



Powers AC. Diabetes Mellitus Harrison’s principles of internal medicine. Sci Res. 2012;344:2968-3003.

Wang C. The relationship between type 2 diabetes mellitus and related thyroid diseases. J Diab Res. 2013;1-9

Vikhe VB, Kanitkar SA, Tamakuwala KK, Gaikwad AN, Kalyan M, Agarwal RR. “Thyroid dysfunction in patients with type 2 diabetes mellitus at tertiary care center”. Nat J Med Res. 2013;3(4):377-80.

Papazafiropoulou A, Sotiropoulos A, Kokolaki A, Kardara M, Stamataki P, Pappas S. Prevalence of thyroid dysfunction among greek type 2 diabetic patients attending an outpatient clinic. J Clini Med Res. 2010 Apr;2(2):75-8.

Nobre E, Jorge Z, Pratas S, Silva C, Castro J. Profile of the thyroid function in a population with type-2 diabetes mellitus. Endocr Abstracts. 2008;3:298.

Radaideh AR, Mo MK, Amari FL, Bateiha AE, El-Khateeb MP, Naser PA, et al. diabetes mellitus in Jordan. Saudi Med J. 2004;25(8):1046-50.

Babu K, Kakar A, Byotra SP. Prevalence of thyroid disorder in type II diabetes mellitus patients. J Assoc Phys Ind. 2001;49:43.

Vondra K, Vrbikova J, Dvorakova K. Thyroid gland diseases in adult patients with diabetes mellitus. Minerva Endocrinol. 2005; 30:217-36.

Celani MF, Bonati ME, Stucci N. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabetes Res. 1994;27(1):15-25.

Michalek AM, Mahoney MC, Calebaugh D. Hypothyroidism and diabetes mellitus in an American Indian population. J Family Pract. 2000; 49(7):53-5.

Whitehead C, Lunt H, Pearson JF, Cawood TJ. Is screening for hypothyroidism in the diabetes clinic effective? Practical Diab. 2010;27(3):113-7.

Schlienger JL, Anceau A, Chabrier G, North ML, Stephan F. Effect of diabetic control on the level of circulating thyroid hormones. Diabetol. 1982 Jun 1;22(6):486-8.

Bazrafshan HR, Ramezani A, Salehi A. Thyroid dysfunction and its relation with diabetes mellitus (NIDDM). J Gorgan Univ Medical Sciences 2000; 2 (5): 5-11.

Ardekani MA, Rashidi M, Shojaoddiny A. Effect of thyroid dysfunction on metabolic response in type 2 diabetic patients. Iranian J Diab Obesity. 2010;2(1): 20-6.

Diez JJ, Sanchez P, Iglesias P. Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp Clin Endicrinol Diab. 2011;119(4):201-7.