Anti- cyclic citrullinated peptide antibodies in tuberculosis and human immunodeficiency virus


  • Rakesh K. Yadav Department of Medicine, M.L.N. Medical College Prayagraj, Uttar Pradesh, India
  • Raj K. Department of Medicine, M.L.N. Medical College Prayagraj, Uttar Pradesh, India
  • Kachnar V. Department of Pathology, M.L.N. Medical College Prayagraj, Uttar Pradesh, India
  • Manoj K. Mathur Department of Medicine, M.L.N. Medical College Prayagraj, Uttar Pradesh, India
  • Amitabh D. Shukla Department of Pulmonary Medicine, M.L.N. Medical College Prayagraj, Uttar Pradesh, India



Anti cyclic citrullinated peptide antibody, Human Immunodeficiency Virus, Tuberculosis


Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have been considered very specific for rheumatoid arthritis (RA). Some studies have shown that these antibodies can be positive in infectious diseases like tuberculosis, human immunodeficiency virus infection, etc.

Methods: Eighty patients of tuberculosis both pulmonary and extra-pulmonary tuberculosis and thirty patients of human immunodeficiency virus were enrolled in this study from inpatient and outpatient departments from September 2018 to August 2019. Anti-CCP antibody test was done in all the patient by enzyme linked immunosorbent assay.

Results: Fifty-three patients were of pulmonary tuberculosis, 27 patients were extra-pulmonary tuberculosis and 30 patients were human immunodeficiency virus infection. Of the 53 cases of pulmonary tuberculosis, 21 (39.6%) cases were positive for anti-CCP antibodies and 32 (60.4%) cases were negative for the same. Of the 27 cases of extra-pulmonary tuberculosis, 3(11.1%) cases were positive for anti-CCP antibodies and 24 (88.9%) cases were negative. Of the 53 patients of pulmonary tuberculosis, 16 were sputum positive and 37 were sputum negative. Of those with

sputum positive 9 (56.2%) cases were positive for anti-CCP antibodies and those with sputum negative, 12 (32.4%) cases were positive for anti-CCP antibodies. Of the 30 cases of human immunodeficiency virus, 5 (16.7%) cases were positive for anti-CCP antibodies and 25 (83.3%) cases were negative.

Conclusions: Anti-CCP can be positive in cases of infectious diseases like tuberculosis and human immunodeficiency virus. Positivity of anti-CCP antibodies for tuberculosis is more for pulmonary (more for sputum-positive than sputum-negative) than extra-pulmonary tuberculosis. Anti-CCP, thus is not very specific for rheumatoid arthritis.


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