Unmasking the diabetic population in pre-diabetic subset of population
Keywords:Diabetes, Fasting plasma glucose, Oral glucose tolerance test, Pre-diabetes, Post prandial plasma glucose
Background: Identification of individuals with a high risk of developing diabetes and early diagnosis of diabetes is essential in prevention and early treatment of diabetes. Effective lifestyle and pharmacologic interventions to delay development of diabetes in people with high risk have been established.
Methods: This Prospective non-randomized interventional study was conducted in 100 Pre diabetic patients who came in OPD of MGM Medical College and MY Hospitals, Indore, MP, from December, 2017 to February, 2019.
Results: OGTT after 1hour was more than160mg/dl and OGTT after 2 hour was more than140mg/dl was found in 40 patients that is 40% of patients. The mean OGTT at 1 hour at presentation was 189.60±28.89 mg/dl and after 6 weeks (first follow-up) was 150.90±14.29mg/dl. The difference was found to be statistically significant (p=0.001), showing a significantly lower OGTT at 1 hour after 6 weeks (first follow-up). The mean OGTT at 1 hour after 6 weeks (first follow-up) was 169.00±3.72 mg/dl and after 6 weeks (second follow-up) was 148.67±6.29 mg/dl. The difference was found to be statistically significant (p=0.001), showing a significantly lower OGTT at 1 hour after 6 weeks (second follow-up) in comparison to follow-up after 6 weeks (first follow-up).
Conclusions: Patients who were labelled as pre-diabetic on the basis of FPG and PPPG may have underlying diabetes which will remain unmasked due to less sensitivity of these tests individually.
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