Analysis of patients of hemophagocytic lymphohistiocytosis secondary to infections

Authors

  • Arundhati G. Diwan Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Supriya S. Barsode Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Amit R. Nisal Department of Pathology, BVDUMC, Pune, Maharashtra, India
  • Ruturaj S. Deshpande Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Mayur D. Patil Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Neeraj S. Shettar Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Vishal C. Lali Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Gargee M. Pore Department of Medicine,BVDUMC, Pune, Maharashtra, India
  • Bhabatosh K. Saha Department of Medicine,BVDUMC, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20204063

Keywords:

Hemophagocytic lymphohistiocytosis, Macrophages, Tropical fever, Haematological malignancies

Abstract

Background: Hemophagocytic lymphohistiocytosis is characterized by an unremitting activation of CD8+ T lymphocytes and macrophages that leads to organ damage.

Methods: 40 patients diagnosed of having HLH secondary to infections admitted in the last 5 years in a tertiary hospital in Western Maharashtra, were studied retrospectively. The data was collected from the indoor patient records and files, detailed clinical profile and all relevant investigations were noted.

Results: 40 cases of diagnosed HLH were studied. Age group of 30-40 years was involved more (25%), followed by age group of 61-70 years. The condition was more common in males (64%). Dengue was more common having more chance of secondary HLH. Early diagnosis and treatment was effective in 90% cases.

Conclusions: HLH was seen to occur more in tropical fevers. The mortality rate was more in haematological malignancies. Early diagnosis and rapidly initiated treatment had a positive effect in decreasing the mortality rate of the condition.

Author Biographies

Arundhati G. Diwan, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Professor

Department of Medicine

Supriya S. Barsode, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Professor 

Department of Medicine

Amit R. Nisal, Department of Pathology, BVDUMC, Pune, Maharashtra, India

Assistant Professor

Department of Pathology

Ruturaj S. Deshpande, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Junior Resident 

Department of Medicine

Mayur D. Patil, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Junior Resident

Department of Medicine

Neeraj S. Shettar, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Junior Resident

Department of Medicine

Vishal C. Lali, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Junior Resident

Department of Medicine

Gargee M. Pore, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Junior resident

Department of Medicine

Bhabatosh K. Saha, Department of Medicine,BVDUMC, Pune, Maharashtra, India

Junior Resident 

Department of Medicine

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Published

2020-09-22

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Section

Original Research Articles