Study of thyroid dysfunction in type 2 diabetes mellitus


  • Mausam Jain Department of Medicine, Smt. B. K. Shah Medical Institute & Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat
  • Pramod R. Jha Department of Medicine, Smt. B. K. Shah Medical Institute & Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat
  • Gaurang Patel Department of Medicine, Smt. B. K. Shah Medical Institute & Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat



Diabetes mellitus type 2, Hyperthyroidism, Hypothyroidism


Background: Aim was to study prevalence of thyroid dysfunction in type II diabetes mellitus (T2DM) patients.

Methods: The present study was a cross sectional observational study, which focused on cases of diabetes mellitus. Study was conducted in Departments of Medicine, SBKS MI & RC, a tertiary care centre for a period of 6 months. All the patients of T2DM were included. Total of 263 patients were enrolled which involved indoor, outpatient and diabetic clinic attending patients. A detailed history taking, clinical examination and relevant investigations (Hb%, Total count, platelet count, serum creatinine, FBS, PP2BS, HbA1C, S.TSH, F.T3 and F.T4). Appropriate statistical analytics were used and important correlations and conclusions were drawn.

Results: A study of thyroid dysfunction (TD) in T2DM patients which included 263 diabetic patients, out of them 67 had thyroid dysfunction. Out of these 67 patients 43 were female and 24 were male. This suggests that female was more prone to thyroid dysfunction than males. Out of 67 TD patients, 42 were above the age of 50 year. So, as the age increases the prevalence of TD also increases thyroid dysfunction also depends on the glycaemic control of the patients. Out of 67 patients 22 patients had>8.0 HbA1C level. In our study we found that as the glycaemic control became poorer the prevalence of TD increase in hypothyroid but not in hyperthyroidism.

Conclusions: Following conclusions were drawn from this study TD is more common in female than male, more after the age of 50 year, in T2DM patients. Hypothyroidism is more common with poor glycaemic control and long duration of T2DM patients. But for hyperthyroidism data which we evaluated was not significant and further conclusion bigger study is needed.


American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabet Car. 2014;37(1):S81-90.

Syed MA, Barinas-Mitchell E, Pietropaolo SL, Zhang YJ, Henderson TS, Kelley DE, et al. Is type 2 diabetes a chronic inflammatory/autoimmune disease?. Diabet Nutrit Metabol. 2002;15(2):68.

Sridhar GR, Nagamani G. Clinical association of autoimmune diseases with DM. Annals New work Acad Sci. 2006.

Feely J, Isles TE. Screening for thyroid dysfunction in diabetics. Br Med J. 1979;1(6179):1678.

Pandey N, Jain S, Baghel PK. Study of Serum Magnesium Level In Type 2 Diabetes Mellitus Patients With Special Emphasis On Microvascular And Macrovascular Complications. Ind J Appl Res. 2019;9(11).

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes- estimates for the year 2000 and projections for 2030. Diabet Car. 2004;27(3):1047-53.

Longo DL, Fauci as, Kasper DL, Hauser SL, Jameson JL Loscalzo J. Harrisons’s Principles of Internal Medicine, 19th edition. 2399.

Silva RC: Arq Bras Endocrinol Metab 2005;49(2):180-2.

Celani MF, Bonati ME, Stucci N. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabet Res. 1994;27(1):15-25.

Chen G, et al: Associations between cardiovascular risk, insulin resistance, P-cell Function and thyroid dysfunction: a cross section study in her ethnic minority group of Fujian Province in China. Euro J Endocrinol. 2010;163:775-82.

Umpierrez GE. Thyroid dysfunction in patients with type 1 diabetes. Diabet Ca. 2003;26:1181-5.

Shah, SN. Thyroid disease in diabetes mellitus. J Assoc Physic Ind. 2007;32(12):1057-59.

Kumar PR, Bhansali A, Ravikiran M. Utility of glycated hemoglobin in diagnosing type 2 diabetes mellitus: a community-based study. J Clin Endocrinol Metab. 2010; 95:2832-5.

Udoing. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Ind J Clin Biochem. 2007;22:74-8.

Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov. 2009;8(4):308-20.

Gharib H. Consensus statement. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the Thyroid Association and The Endocrine Society. J Clin Endocrinol Metab. 2005;90:581-5.

Nassiri S, Vakili M, Gholami H, Akhavan S. Prevalence of thyroid dysfunction in patient of type 2 diabetes mellitus: hospital based prospective study. Int J Curr Res. 2014;10(03):67031-4.

Rehman A, Mohamad K. Thyroid dysfunction in type II diabetes mellitus in Jordan. Saudi Med J. 2004;25(8):1046-50.

Singh AP, Sharma R. Study of thyroid dysfunction in patients of type 2 diabetes mellitus. Int J Appl Resear. 2017;3(12):84-7.






Original Research Articles