Fatality in COVID 19: an overview of causes of death and organ involvement

Authors

  • Shivangi Garima Department of Anatomy, DY Patil University, School of Medicine, Nerul, Navi Mumbai, Maharashtra, India
  • Nihaal Singh MBBS Student, Jawaharlal Nehru Medical College, DMIMS (DU), Wardha, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20202598

Keywords:

ARDS, Cause of death, COVID-19, Coronavirus, SARS CoV-2, Organ involvement, Pandemic, Post-mortem

Abstract

COVID-19 is a viral infectious disease caused by the SARS CoV-2 virus, which is a respiratory pathogen. It originated in the city of Wuhan in China from where it spread throughout the world. This virus causes severe respiratory distress in a certain number of patients with specific risk factors. In our article, authors plot the route from the onset of the disease to its progress to death in patients, and determine the most likely causes that lead to such a poor prognosis. Authors also evaluate the severity and extent of organ damage that is involved and associated with fatality in cases with COVID-19. Authors also aim for clinicians to better understand and perceive the circumstances under which a patient may progress from severe infection towards death, and manage such cases in a more efficient manner.

References

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Tian S, Xiong Y, Liu H, Niu L, Guo J, Liao M. et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Modern Pathol. 2020.

Leung C. Clinical features of deaths in the novel coronavirus epidemic in China. Rev Med Virol. 2020;30:e2103.

Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020.

Hanley B, Lucas S, Youd E, Swift B, Osborn M. Autopsy in suspected COVID-19 cases. J Clin Pathol. 2020;73(5):239-42.

Wang T, Du Z, Zhu F, Cao Z, An Y, Gao Y, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet. 2020;395(10228):e52.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62.

Downloads

Published

2020-06-22

Issue

Section

Review Articles