A comparative study of the relationship between uric acid with the severity of coronary artery disease
Keywords:Coronary artery disease, Gensini scoring system, Uric acid
Background: Coronary Artery disease (CAD) is defined as the presence of stenosis of atleast 50% of the vessel diameter in any of the main coronary arteries. Coronary Artery Disease (CAD) is the leading cause of death worldwide. According to WHO estimates, 17.5 million people died of CAD in 2005. Uric acid (UA) is the end product of purine nucleotide metabolism, it could induce the proliferation and inflammation of vascular smooth muscle cells. This study is undertaken to evaluate the role of serum uric acid levels in severity CAD in our centre.
Methods: This is a cross sectional study of 120 patients with CAD visiting the OPD or admitted in Medicine department at hospitals attached to BMCRI between June 2018 to July 2019. All CAD patients were assessed for the presence of comorbid conditions and ongoing medications. Serum Uric acid levels, creatinine level, fasting lipid profile were measured in all patients before Coronary Angiogram. The severity of CAD (percentage of stenosis) was assessed by the Gensini scoring system.
Results: Of 120 CAD patients’ majority were in the age group of 51-60 years, 89 were men and 31 were women. Of the study patients, 93 (77.5%) symptoms like chest pain and/or breathlessness, 84 (70%) had a smoking history, 43 (35.8) had gensini score of 4 with uric acid levels of (mean 5.49), 26 (21.7%) had gensini score of 8 with uric acid levels of (mean 6.36), 49 (40.8%) had gensini score of 16 with uric acid levels of (mean 7.03) and 2 (1.7%) had gensini score of 32 with uric acid levels of (mean 7.35). Based on this analysis, we found that serum uric acid levels were in linear correlation with the severity of CAD.
Conclusions: In conclusion, serum uric acid levels were found to be associated with the severity of CAD.
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