Published: 2020-06-22

A comparative study of the relationship between uric acid with the severity of coronary artery disease

Nirmala A. C., Chetan H.


Background: Coronary Artery disease (CAD) is defined as the presence of stenosis of atleast 50% of the vessel diameter in any of the main coronary arteries. Coronary Artery Disease (CAD) is the leading cause of death worldwide. According to WHO estimates, 17.5 million people died of CAD in 2005. Uric acid (UA) is the end product of purine nucleotide metabolism, it could induce the proliferation and inflammation of vascular smooth muscle cells. This study is undertaken to evaluate the role of serum uric acid levels in severity CAD in our centre.

Methods: This is a cross sectional study of 120 patients with CAD visiting the OPD or admitted in Medicine department at hospitals attached to BMCRI between June 2018 to July 2019. All CAD patients were assessed for the presence of comorbid conditions and ongoing medications. Serum Uric acid levels, creatinine level, fasting lipid profile were measured in all patients before Coronary Angiogram. The severity of CAD (percentage of stenosis) was assessed by the Gensini scoring system.

Results: Of 120 CAD patients’ majority were in the age group of 51-60 years, 89 were men and 31 were women. Of the study patients, 93 (77.5%) symptoms like chest pain and/or breathlessness, 84 (70%) had a smoking history, 43 (35.8) had gensini score of 4 with uric acid levels of (mean 5.49), 26 (21.7%) had gensini score of 8 with uric acid levels of (mean 6.36), 49 (40.8%) had gensini score of 16 with uric acid levels of (mean 7.03) and 2 (1.7%) had gensini score of 32 with uric acid levels of (mean 7.35). Based on this analysis, we found that serum uric acid levels were in linear correlation with the severity of CAD.

Conclusions: In conclusion, serum uric acid levels were found to be associated with the severity of CAD.


Coronary artery disease, Gensini scoring system, Uric acid

Full Text:



Yuksel M. The association between platelet/Lymphocyte ratio and coronary artery disease severity. Anotol J Cardiol. 2015;15(8):640-7.

Amin MR, Rahman MA, Alam N, Hasan MN, Hasan GS. Relationship between triglyceride HDL-Cholesterol ratio and severity of coronary artery disease in patient with acute coronary syndrome. Bangladesh Medical J. 2016; 43(3):157-61.

Tian TT, Li H, Chen SJ, Wang Q, Tian QW, Zhang BB, Zhu J, He GW, Lun LM, Xuan C. Serum uric acid as an independent risk factor for the presence and severity of early-onset coronary artery disease: a case-control study. Disease markers. 2018:1-8.

Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrisons Principles of Internal Medicine. 20th edition. Mc Graw Hill Publication; 2018:1614-1632.

Lv S, Liu W, Zhou Y, Liu Y, Shi D, Zhao Y, et al. Hyperuricemia and smoking in young adults suspected of coronary artery disease≤ 35 years of age: a hospital-based observational study. BMC cardiovascular disorders. 2018 Dec 1;18(1):178.

Larsen TR, Gerke O, Diederichsen AC, Lambrechtsen J, Steffensen FH, Sand NP, et al. The association between uric acid levels and different clinical manifestations of coronary artery disease. Coronary artery disease. 2018 May 1;29(3):194-203.

Bagheri B, Zargari M, Meshkini F, DinarvanD K, Mokhberi V, Azizi S, et al. Uric acid and coronary artery disease, two sides of a single coin: A determinant of antioxidant system or a factor in metabolic syndrome. J Clini Diagnostic Res: JCDR. 2016 Feb;10(2):OC27.

Qureshi AE, Hameed S, Noeman A. Relationship of serum uric acid level and angiographic severity of coronary artery disease in male patients with acute coronary syndrome. Pak J Med Sci. 2013;29(5):1137.

Akanda MA, Choudhury KN, Ali MZ, Naher S, Islam AS, Ali MI. Serum uric acid and its association with coronary artery disease. Cardiovascular J. 2012 Oct 16;5(1):12-7.

Sinan Deveci O, Kabakci G, Okutucu S, Tulumen E, Aksoy H, Baris Kaya E, et al. The association between serum uric acid level and coronary artery disease. International J Clini Pract. 2010 Jun;64(7):900-7.

Goodarzynejad H, Anvari MS, Boroumand MA, Karimi A, Abbasi SH, Davoodi G. Hyperuricemia and the presence and severity of coronary artery disease. Lab Med. 2010 Jan 1;41(1):40-5.

Lim HE, Kim SH, Kim EJ, Kim JW, Rha SW, Seo HS, et al. Clinical value of serum uric acid in patients with suspected coronary artery disease. Korean J Int Med. 2010 Mar;25(1):21.