Serum uric acid level in Bangladeshi adults with essential hypertension


  • SK. Kabir Ahammed Department of Medicine, Sylhet M.A.G. Osmani Medical College Hospital, Sylhet, Bangladesh
  • A. B. M. Kamrul Hasan Department of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh
  • Mohammed Ruhul Kabir Department of Medicine, Sylhet M.A.G. Osmani Medical College Hospital, Sylhet, Bangladesh
  • Gunosindhu Paul Department of Medicine, 30-Bed Khadimpara Hospital, Sylhet, Bangladesh
  • Shishir Kumar Basak Department of Medicine, Sylhet M.A.G. Osmani Medical College Hospital, Sylhet, Bangladesh
  • Shishir Ranjan Chakraborty Department of Medicine, Sylhet M.A.G. Osmani Medical College Hospital, Sylhet, Bangladesh
  • A.F.M. Nazmul Islam Department of Medicine, Sylhet M.A.G. Osmani Medical College Hospital, Sylhet, Bangladesh



Essential hypertension, Hypertension, Hyperuricemia, Uric acid


Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.

Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.

Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.

Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.


Singh S, Shankar R, Singh GP. Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. Int J Hypertens. 2017;2017:5491838.

Queasem I, Shetye SM, Alex SC. Prevalence, awareness, treatment and control of hypertension among the elderly in Bangladesh and India. Bull World Health Organ. 2001;79(6):490-500.

Bolívar JJ. Essential hypertension: an approach to its etiology and neurogenic pathophysiology. Int J Hypertens. 2013;2013:547809.

Bauer RGEG, Ewan CE, Neale FC. Serum Uric Acid in Normal and Hypertensive Australian Subjects: From a Continuing Epidemiological Survey on Hypertension Commenced in 1955. Internal Med J. 1972;2(4):351-6.

Afifi A, Sarhan I, El Sharkawy M, Kamel M, Anwar W, Helmy N, et al. Uric Acid Metabolism in a Sample of Egyptian Hypertensive Patients With Normal Kidney Function. Egyptian J Hospital Med. 2013(1);52:608-14.

Ahmed N, Anwar W, Waqas H. Obesity, hyperlipidemia and hyperuricemia in young and old hypertensive patients. J Ayub Med Coll Abbottabad. 2009;21(4):53-6.

Poudel B, Yadav BK, Kumar A, Jha B, Raut KB. Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study. Asian Pac J Trop Biomed. 2014;4(1):59-64.

Neki NS, Tamilmani. A Study of Serum Uric Acid level in Essential Hypertension. J Int Med Sci Academy. 2015;28(1):13.

Shah M, Godbole V, Parmar U, Gosai F, Pathak T. A study to assess relationship between Uric Acid and Blood pressure among patients attending tertiary care hospital in Central Gujarat. Int J Res Med. 2015;4(3):24-8.

Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003;42(4):474-80.

Sundstrom J, Sullivan L, D’Agostino RB, Levy D, Kannel WB, Vasan RS. Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence. Hypertension. 2005;45(1):28-33.

Shankar A, Klein R, Klein BE, Nieto FJ. The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study. J Hum Hypertension. 2006;20(12):937-45.

Mellen PB, Bleyer AJ, Erlinger TP, Evans GW, Nieto FJ, Wagenknecht LE, et al. Serum uric acid predicts incident hypertension in a Biethnic Cohort: the Atherosclerosis Risk in Communities Study. Hypertension. 2006;48(6):1037-42.

Perlstein TS, Gumieniak O, Williams GH, Sparrow D, Vokonas PS, Gaziano M, et al. Uric acid and the development of hypertension: the normative aging study. Hypertension. 2006;48(6):1031-6.

Zaman MM, Rouf vMA. Prevalence of hypertension in a Bangladeshi adult population. J Human Hypertens. 1999;13(8):547-9.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Jones DW et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-52.

Bachorik PS, Ross JW. National cholesterol education program recommendations for measurement of low-density lipoprotein cholesterol: Executive summary. Clinical Chemistry. 1995;41(10):1414-20.

Kemperman FA, Krediet RT, Arisz L. Formula-derived prediction of the glomerular filtration rate from plasma creatinine concentration. Nephron. 2002;91(4):547-58.

Meti K, Gaddeppanavar J, Karinagannanavar A, Shashikantha, Girish I. Estimation of serum uric acid level in essential hypertension and its correlation with severity and duration of hypertension. Int J App Res. 2015;1(9):844-8.

Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension. 2000;36(6):1072-8.

Buzas R, Tautu OF, Dorobantu M, Ivan V, Lighezan D. Serum uric acid and arterial hypertension-Data from Sephar III survey. PLoS One. 2018;13:e0199865.

Kuroczycka-Saniutycz E, Wasilewska A, Sulik A, Milewski R. Urinary angiotensinogen as a marker of intrarenal angiotensin II activity in adolescents with primary hypertension. Pediatr Nephrol. 2013;28(7):1113-9.

Zhou X, Matavelli L, Frohlich ED. Uric acid: its relationship to renal hemodynamics and the renal renin-angiotensin system. Curr Hypertens Rep. 2006;8(2):120-4.

Babinska K, Kovacs L, Janko V, Dallos T, Feber J. Association between obesity and the severity of ambulatory hypertension in children and adolescents. J Am Soc Hypertens. 2012;6(5):356-63.

Yoo TW, Sung KC, Shin HS, Kim BJ, Kim BS, Kang JH, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J. 2005;69(8):928-33.

Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens. 2008;26(2):269-75.

Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res. 2012;35(11):1039-47.

Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005;16(12):3553-62.

Kashem MA, Hossain MZ, Ayaz KM, Alam MB, Khan MH, Alam AB, et al. Relation of serum uric acid level and essential hypertension among patients without metabolic syndrome. J Dhaka Med Coll. 2011;20(1):5-8.






Original Research Articles