Evaluating serum uric acid levels in patients with acute myocardial infarction
Keywords:Cardiovascular disease, Heart failure, Hyperuricemia, Smoking
Background: Elevated levels of serum uric acid are associated with increased cardiovascular morbidity and mortality. However, this association with cardiovascular diseases is still unclear, and perhaps controversial. The objective of study was to assess the serum uric acid level in patients with Acute Myocardial Infarction (AMI).
Methods: Sixty patients with AMI were studied in Department of Medicine/ Department of Cardiology, J.A. Group of Hospitals between 2016 -2018.Details of age, sex, smoking, alcohol consumption and history of ischemic heart disease (IHD) was obtained and recorded. Serum uric acid level was estimated and compared with control group (healthy subjects).
Results: Serum uric acid level was significantly higher among AMI patients (6.43±2.60) as compared to control group (4.05±0.95) (p<0.001). Majority (46.7%) of the AMI patients had uric acid level of >7.1 followed by 20% patients who had uric acid level between 4.5-5.9 (p<0.001). Uric acid level was comparable between smoker and non-smokers (p=0.803), alcoholic and non-alcoholic (p=0.086), hypertensive and non-hypertensive (p=0.668), patients with and without diabetes (p=0.278) and patients with a history of IHD and without history of IHD (p=0.403).
Conclusions: Serum uric acid may be useful for prognostication among those with pre-existing AMI.
Wannamethee SG, Papacosta O, Lennon L, Whincup PH. Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment: The British Regional Heart Study. Int J Cardiol. 2018;252:187-92.
Kenchaiah S, Narula J, Vasan RS. Risk factors for heart failure. Med Clin North Am. 2004;88:1145-72.
Miller WL, Hartman KA, Burritt MF. Serial biomarker measurements inambulatory patients with chronic heart failure: the importance of change overtime. Circulation. 2007;116:249-57.
Leyva F, Anker S, Swan JW, Godsland IF, Wingrove CS, Chua TP et al. Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure. Eur Heart J. 1997;18:858-65.
Harris P, Feroz P Jenner, Sunil Kumar. Serum uric acid as a marker of left ventricular failure in acute myocardial infarction. (IOSR-JDMS). 2015;14(11):102-09.
Joshi P, Islam S, Pais P, Reddy S, Dorairaj P, Kazmi K et al. Risk Factors for Early Myocardial Infarction in South Asians Compared With Individuals in Other Countries. JAMA. 2007;297(3):286-94.
Behera SK, Samal AK. Study of serum uric acid level as a prognostic marker in acute ST elevation myocardial infarction patients. Int J Adv Med. 2018;5:592-6.
Bickel C, Rupprecht HJ, Blankenberg S, Rippin G, Hafner G, Daunhauer A, et al. Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease. Am J Cardiol. 2002;89(1):12-7.
Padma V, Banupriya A. Serum uric acid levels in acute myocardial infarction. Int J Adv Med. 2017;4:1010-3.
Kojima S, Sakamoto T, Ishihara M. Prognostic usefulness of serum uric acid after acute myocardial infarction (Japanese Acute Coronary Syndrome Study). Am J Cardiol. 2005;96:489-95.
Jularattanaporn V, Krittayaphong R, Boonyasirinant T, Udol K, Udompunurak S. Prevalence of Hyperuricemia in Thai Patients with Acute Coronary Syndrome. Thai Heart J 2008;21:86-92.
Jacobs D. Hyperuricaemia and myocardial infarction. S Afr Med J. 1972;46:367-9.
Sokhanavar S, Maleki A. Blood uric acid levels according to cardiovascular disease risk factors in patients with myocardial infarction. Iranian Heart J. 2007;8(1):43-5.