Influence of sleep in polycystic ovarian syndrome: an ayurvedic appraisal
DOI:
https://doi.org/10.18203/2349-3933.ijam20203133Keywords:
Ayurveda, Hormonal cycle, Metabolic health, Nidra, Polycystic ovary syndromeAbstract
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder which affects the reproductive, metabolic and psychological health of women. Now a day’s incidence rate of PCOS is incising in reproductive age of woman due to sedentary lifestyle and faulty daily routine. Clinical studies indicate that sleep disturbance and disorders including obstructive sleep apnea and excessive daytime sleepiness are more common in the woman with symptoms of PCOS. Despite proof of the high prevalence of sleep disorders in these patients, modification of sleep is not considered as major point for treatment protocol in modern therapeutics. Ayurveda as a holistic medicine lays great emphasis on lifestyle modification under Aahaara (Diet)- Vihaara (Daily regimen)- Oushadha (Medicine) - triad for the prevention and treatment of all diseases. Among Vihaara, Nidra (Sleep) is considered as a very influencing factor in Ayurvedic classics. Balanced sleep at night maintains the health. Disturbance of sleep pattern can lead to Dosha vitiation which hampers regular metabolic activity of the body and leads to various disorders. Hormones affecting metabolism, appetite and blood glucose are regulated with circadian rhythms. When circadian rhythms are out of sync, the body’s metabolic health hampers. Irregular metabolic function disturbs the hormonal cycle including hypothelamo-pitutory-ovarian axis, hypothalamic–pituitary–adrenal function, and so on. These can ultimately lead to PCOS in reproductive age of women. It seems that if lifestyle modification should be expanded in PCOS patients including sleep hygiene alongside food and exercise positive outcome can be obtained. With this background this study is aimed to determine the importance of sleep hygiene in PCOS from the view of Ayurveda.
References
Hugar AL, Kanjikar AP, Londonkar RL. Polycystic ovary syndrome (PCOS)-a mini review. Gynecol. 2018;3(1):000148.
Hung JH, Hu LY, Tsai SJ, Yang AC, Huang MW, Chen PM, et al. Risk of psychiatric disorders following polycystic ovary syndrome: A nationwide population-based cohort study. PLoS One. 2014;9:97041.
Tasali E, Chapotot F, Leproult R, Whitmore H, Ehrmann DA. Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011;96:365-74.
Sam S, Dunaif A. Polycystic ovary syndrome: Syndrome XX? Trends Endocrinol Metab. 2003;14:365-70.
Vgontzas AN, Bixler EO, Chrousos GP. Metabolic disturbances in obesity versus sleep apnoea: The importance of visceral obesity and insulin resistance. J Intern Med. 2003;254:32-44.
Rajaeieh G, Marasi M, Shahshahan Z, Hassanbeigi F, Safavi SM. The relationship between intake of dairy products and polycystic ovary syndrome in women who referred to Isfahan University of Medical Science Clinics in 2013. Int J Prev Med. 2014;5:687-94.
Setji TL, Brown AJ. Polycystic ovary syndrome: Update on diagnosis and treatment. Am J Med. 2014;127:912-9.
Kang X, Jia L, Shen X. Manifestation of hyperandrogenism in the continuous light exposure-induced PCOS rat model. Biomed Res Int. 2015:943694.
Agnivesh: Charak Samhita Edited by Shastri Satyanarayana 1st edn Rprint, Varanasi; Chau Khambha Bharti Academy; 2005:418.
Conway G, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Franks S, Gambineri A, et al. The polycystic ovary syndrome: A position statement from the European Society of Endocrinology. Eur J Endocrinol. 2014;171:1-29.
Konar Hiralal, D.C. Dutta’s Textbook of Gynecology, 17th edn, Jaypee Brothers Medical Publishers (P) Ltd; 2016:380-381.
Agnivesha: Charak Samhita Edited by Sharma P.V. Jaikrishnadas Ayurved Series. 4th Edn Varanasi; Chaukhambha Orientalia; 2000.
Srikantha Murthy, Prof K. R. Ashtamg Hridayam; 4th edn Varanasi. Krishnadas Academy; 1999.
Nimgade D, Bhutada S. Nidra And Nidranasha -An Ayurvedic Critical Review. IAMJ. 2017;5(8):3082-9.
Acharya JT. Caraka Samhita. 1st edn, Varanasi; Chowkamba Prakashan; Reprint; 2001:118-119.
Stachenfeld NS, Yeckel CW, Taylor HS. Greater exercise sweating in obese women with polycystic ovary syndrome compared with obese controls. Med Sci Sports Exerc. 2010;42:1660-8.
Kimura T, Ho IK, Yamamoto I. Uridine receptor: Discovery and its involvement in sleep mechanism. Sleep. 2001;24:251-60.
Sadock BJ, Sadock VA. 5th edn. Philadelphia: Lippincott Williams and Wilkins. Kaplan and Sadock's Pocket Handbook of Clinical Psychiatry; 2010:278-279.
Liu X, Forbes EE, Ryan ND, Rofey D, Hannon TS, Dahl RE, et al. Rapid eye movement sleep in relation to overweight in children and adolescents. Arch Gen Psychiatr. 2008;65:924-32.
Vagbhata, Ashtanga Sangraha, Saroja Hindi Vyakhya by Dr. Ravidatta Tripathi, Chaukambha Sanskrit Pratishtana Reprint, Sutrasthana; 2006:197.
El-Sharkawy AA, Abdelmotaleb GS, Aly MK, Kabel AM. Effect of metformin on sleep disorders in adolescent girls with polycystic ovarian syndrome. J Pediatr Adolesc Gynecol. 2014;27:347-52.
Naqvi SH, Moore A, Bevilacqua K, Lathief S, Williams J, Naqvi N, et al. Predictors of depression in women with polycystic ovary syndrome. Arch Womens Ment Health. 2015;18:95-101.
Moran LJ, March WA, Whitrow MJ, Giles LC, Davies MJ, Moore VM, et al. Sleep disturbances in a community-based sample of women with polycystic ovary syndrome. Hum Reprod. 2015;30:466-72.
Tasali E, Van Cauter E, Ehrmann DA. Polycystic ovary syndrome and obstructive sleep apnea. Sleep Med Clin. 2008;3:37-46.
Naqvi SH, Moore A, Bevilacqua K, Lathief S, Williams J, Naqvi N, et al. Predictors of depression in women with polycystic ovary syndrome. Arch Womens Ment Health. 2015;18:95-101.
Vgontzas AN, Bixler EO, Chrousos GP. Metabolic disturbances in obesity versus sleep apnoea: The importance of visceral obesity and insulin resistance. J Intern Med. 2003;254:32-44.
Northwestern Now. Circadian clock controls insulin and blood sugar in pancreas. Available at: https://news.northwestern.edu/stories/2015/11/circadian-clock-controls-insulin-and-blood-sugar-in-pancreas Accessed on 6 November 2015.
Minkel J, Moreta M, Muto J, Htaik O, Jones C, Basner M, et al. Sleep deprivation potentiates HPA axis stress reactivity in healthy adults. Health Psychol. 2014;33:1430-4.
Naghizadeh MM, Zafari Zangeneh F, Abdollahi A, Bagheri M. Synchrony between ovarian function and sleep in polycystic ovary syndrome patients. Open J Obstet Gynecol. 2014;4:725-31.
Kakizaki M, Kuriyama S, Sone T, Ohmori-Matsuda K, Hozawa A, Nakaya N, et al. Sleep duration and the risk of breast cancer: The ohsaki cohort study. Br J Cancer. 2008;99:1502-5.
Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol. 2004;25:177-95.
Kohyama J. Neurochemical and neuropharmacological aspects of circadian disruptions: An introduction to asynchronization. Curr Neuropharmacol. 2011;9:330-41.
Kakizaki M, Kuriyama S, Sone T, Ohmori-Matsuda K, Hozawa A, Nakaya N, et al. Sleep duration and the risk of breast cancer: The ohsaki cohort study. Br J Cancer. 2008;99:1502-5.
Zangeneh FZ, Naghizadeh MM, Abdollahi A, Bagheri M. Evaluation of Neurohormones in sleep pattern of patients with polycystic ovary syndrome. Iran J Obstet Gynecol Infertil. 1393;17:10-20.
Tamura H, Nakamura Y, Korkmaz A, Manchester LC, Tan DX, Sugino N, et al. Melatonin and the ovary: Physiological and pathophysiological implications. Fertil Steril. 2009;92:328.
Luboshitzky R, Herer P, Shen-Orr Z. Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women: The effect of cyproterone acetate-ethinyl estradiol treatment. Exp Clin Endocrinol Diabetes. 2004;112:102-7.
Tamura H, Nakamura Y, Korkmaz A, Manchester LC, Tan DX, Sugino N, et al. Melatonin and the ovary: Physiological and pathophysiological implications. Fertil Steril. 2009;92:329.
Naqvi SH, Moore A, Bevilacqua K, Lathief S, Williams J, Naqvi N, et al. Predictors of depression in women with polycystic ovary syndrome. Arch Womens Ment Health. 2015;18:95-101.
Moran LJ, March WA, Whitrow MJ, Giles LC, Davies MJ, Moore VM, et al. Sleep disturbances in a community-based sample of women with polycystic ovary syndrome. Hum Reprod. 2015;30:466-72.
Tasali E, Van Cauter E, Ehrmann DA. Polycystic ovary syndrome and obstructive sleep apnea. Sleep Med Clin. 2008;3:37-46.
Zafari ZF, Naghizadeh MM, Abdollahi A, Bagheri M. Synchrony between ovarian function and sleep in polycystic ovary syndrome patients. Open J Obstet Gynecol. 2014;4:725-31.
Yoga for Better Sleep - Harvard Health Blog - Harvard Health Publishing. Available at: https://www.health.harvard.edu/blog/8753-201512048753. Accessed 11 November 2019.
