Profile of patients undergoing third line anti-retroviral therapy

Authors

  • Dhileeban Maharajan P. Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • T. Jeetenkumar Singh Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • S. Bhagyabati Devi Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • H. Rebachandra Singh Department of Microbiology, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Dipul Rudra Paul Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
  • Janani L. Department of Community Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20203605

Keywords:

ART, Darunavir, Failure, HIV, Raltegravir, Ritonavir, Third-line

Abstract

Background: India has the third largest human HIV epidemic in the world. The advent of antiretroviral drug began a revolution in the management of HIV. Recent studies have shown that an increasing number of patients experiencing virologic failure on second line Antiretroviral therapy and require third line ART.

Methods: This prospective cohort study was conducted in Regional Institute of Medical Sciences, Imphal for a period of two years, to study the clinical, immunological, and virological profile of patients undergoing third line Antiretroviral therapy and to study the early immuno-virological response to third line Antiretroviral therapy.

Results: Mean CD4 count before third line ART initiation was 95.90±111.85 cells/μl with 60% of them had CD4 count <100 cells/μl. The mean CD4 count improved significantly (p<0.005) to 246.70±123.78 cells/μl after six months and 340.70±198.57 cells/μl after one year of the therapy. At the time of initiation of third line ART, none of the patients had viral load <150copies/ml while 60% of the population had viral load >100000 copies/ml. After one year of third line ART, 80 % of the patients showed viral suppression (VL<150copies/ml). At the end of one year, the improvement in CD4 count comparing to the Viral load was significant in those who showed viral suppression (VL<150 copies/ml).

Conclusions: This study showed significant improvement in the CD4 count and viral suppression with third line medication without any major clinical adverse effect.

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Published

2020-08-25

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Original Research Articles