Estimation of prevalence of dengue viral infection among clinically suspected patients attending a tertiary care centre in Uttar Pradesh, India
DOI:
https://doi.org/10.18203/2349-3933.ijam20203607Keywords:
Dengue virus infections, Immunoglobulin M antibodies, Mosquito borne diseases, Non-structural protein antigenAbstract
Background: Dengue virus infection is fastest spreading, mosquito borne viral disease in the world with an estimated 3.9 billion people at risk of infection. Dengue is notifiable disease in India, but real number of cases could not be identified many times due to the under-reporting or misdiagnosis of cases. The purpose of the present study was to estimate prevalence of dengue viral Infection among suspected patients attending a tertiary care centre.
Methods: Blood samples from suspected patients were collected over a period of 1 year and were analysed for dengue virus specific IgM antibodies and NS1 antigen by immuno-chromatographic method.
Results: Total 196 samples were tested out of which 43 (21.43%) showed laboratory evidence of dengue. Maximum samples were received during monsoon and post-monsoon period. Dengue sero-positivity was found to be highest in post monsoon period i.e., October-November. Maximum dengue positivity rate was found in the age group of 16-45 years.
Conclusions: For estimation of true burden of dengue in India and its geographical mapping to control further disease transmission; laboratory-based active surveillance systems are required along with passive surveillance and control programs.
References
Jing Q, Wang M. Dengue epidemiology. Glob Heal J. 2019;3(2):37-45.
Dengue and severe dengue. Available at: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. Accessed on 11th July 2020.
Singh DSP, Nayak DM, Singh DM, Sharma DRK, Singh DS. Clinical profile of dengue fever patients in tertiary care hospital of North India. Pediatr Rev Int J Pediatr Res. 2019;6(3):129-33.
Gupta E, Ballani N. Current perspectives on the spread of dengue in India. Infect Drug Resist. 2014;7:337-42.
Murhekar M, Joshua V, Kanagasabai K, Shete V, Ravi M, Ramachandran R, et al. Epidemiology of dengue fever in India, based on laboratory surveillance data, 2014-2017. Int J Infect Dis. 2019;84:S10-S14.
Rao C, Kaur H, Gupta N, Sabeena SP, Ambica R, Jain A, et al. Geographical distribution of primary and secondary dengue cases in India-2017: a cross-sectional multicentric study. Indian J Med Res. 2019;149(4):548.
Swain S, Bhatt M, Pati S, Soares Magalhaes RJ. Distribution of and associated factors for dengue burden in the state of Odisha, India during 2010-2016. Infect Dis Poverty. 2019;8(1):1-10.
Murhekar MV, Kamaraj P, Kumar MS, Khan SA, Allam RR, Barde P, et al. Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey. Lancet Glob Heal. 2019;7(8):e1065-e1073.
Carabali M, Hernandez LM, Arauz MJ, Villar LA, Ridde V. Why are people with dengue dying? A scoping review of determinants for dengue mortality. BMC Infect Dis. 2015;15(1):1-14.
Bhavsar A, Tam CC, Garg S, Jammy GR, Taurel AF, Chong SN, et al. Estimated dengue force of infection and burden of primary infections among Indian children. BMC Public Health. 2019;19(1):6-11.
Chakravarti A, Arora R, Luxemburger C. Fifty years of dengue in India. Trans R Soc Trop Med Hyg. 2012;106(5):273-82.
Mutheneni SR, Morse AP, Caminade C, Upadhyayula SM. Dengue burden in India: Recent trends and importance of climatic parameters. Emerg Microbes Infect. 2017;6(8):1-10.
Chaturvedi UC, Nagar R. Dengue and dengue haemorrhagic fever: Indian perspective. J Biosci. 2008;33(4):429-441.
Sharma RS, Kumari R, Srivastava PK, Barua K, Chauhan LS. Emergence of dengue problem in India - a public health challenge. J Commun Dis. 2014;46(2):17-45.
Gupta E, Dar L, Kapoor G, Broor S. The changing epidemiology of dengue in Delhi, India. Virol J. 2006;3:2003-7.
Jain S, Dixit G, Kohli V. Trend and epidemiological profile of dengue fever/dengue haemorrhagic fever in Ahmedabad City, Gujarat, India. Healthline, J Indian Associat Prevent Social Med. 2019;10(1):62-7.
Shastri J, Williamson M, Vaidya N, Agrawal S, Shrivastav O. Nine-year trends of dengue virus infection in Mumbai, Western India. J Lab Physicians. 2017;9(04):296-302.
Dar L, Broor S, Sengupta S, Xess I, Seth P. The first major outbreak of dengue hemorrhagic fever in Delhi, India. Emerg Infect Dis. 1999;5(4):589-90.