Tryptase plays a role in solid tumor angiogenesis and cell proliferation

Authors

  • Anisha Mathew Department of Biochemistry, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India http://orcid.org/0000-0003-3151-7603
  • Manisha Naithani Department of Biochemistry, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India http://orcid.org/0000-0003-1144-4478
  • Amit Sehrawat Department of Medical Oncology Hematology, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India http://orcid.org/0000-0001-7100-8999
  • Deepak Sundriyal Department of Medical Oncology Hematology, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India http://orcid.org/0000-0002-6378-7694
  • Pulturu Venkata Shilpa Department of Biochemistry, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India
  • Uttam Kumar Nath Department of Medical Oncology Hematology, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India http://orcid.org/0000-0001-7762-803X

DOI:

https://doi.org/10.18203/2349-3933.ijam20203610

Keywords:

Solid tumor, Tryptase, Tumor angiogenesis

Abstract

Tryptase, a serine protease released during mast cell degranulation has been associated with anaphylactic reactions and inflammations. In recent studies on solid tumor proliferation, it has been seen that tryptase has a role in tumor angiogenesis and tumor cell proliferation. This also makes tryptase a potential therapeutic target. Many anti-tryptase agents have shown to decrease tumor angiogenesis and proliferation. Authors have thus reviewed various articles which have done extensive studies on the role of tryptase as an important factor in tumor proliferation and angiogenesis.

Author Biographies

Anisha Mathew, Department of Biochemistry, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India

Academic Junior Resident

AIIMS, Rishikesh

Manisha Naithani, Department of Biochemistry, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India

Additional Professor
Department of Biochemistry
AIIMS, Rishikesh

Amit Sehrawat, Department of Medical Oncology Hematology, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India

Assistant professor

Department of Medical oncology Hematology

AIIMS, Rishikesh

Deepak Sundriyal, Department of Medical Oncology Hematology, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India

Assistant Professor

Department of Medical Oncology Hematology

AIIMS, Rishikesh

Pulturu Venkata Shilpa, Department of Biochemistry, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India

Academic Junior Resident

Department of Biochemistry

AIIMS, Rishikesh

Uttam Kumar Nath, Department of Medical Oncology Hematology, All India Institute Medical Sciences Rishikesh, Rishikesh, Uttarakhand, India

Additional Professor

Department of Medical Oncology Hematology

AIIMS, Rishikesh

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Published

2020-08-25

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Review Articles