Effect of hypothyroidism on glycemic control in type 2 diabetics

Authors

  • Jayant K. Golwalkar Department of General Medicine, Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari, Maharashtra, India
  • Sachin Gudge Department of General Medicine, Bidar Institute of Medical Sciences, Udgir Road, Bidar, Karnataka, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20205477

Keywords:

Euthyroid, Subclinical hypothyroidism, Clinical hypothyroidism, Type 2 diabetes

Abstract

Background: The major cause for complications of diabetes is hyperglycemia which can be prevent or reversing complications by using key effective blood sugar control and improving the life quality. Recognizing the link between thyroid disease and diabetes is important to guide clinicians in optimal management of both conditions. Therefore, the current study is undertaken to study the effects of thyroid disease on glycerin administration in patients with type 2 diabetes mellitus (DM).

Methods: The present cross-sectional study was carried out in the Department of General Medicine, ARMCH and RC, Kumbhari during study period of two years. All patients with type 2 diabetics who met the inclusion and exclusion criteria during the study period were sampled for the present study. Baseline data were recorded, including medical history, family history, drug history, and personal history. Clinical data was collected by using pre-structured questionnaires.

Results: In the present study, Euthyroid was 84%, subclinical hypothyroidism was 12% and clinical hypothyroidism was 4%. Majority of the subjects belongs to age group of 51-60 years (36%). The association of hypothyroidism was found to be significant with glycated hemoglobin (HbA1c), duration of DM, electrocardiography (ECG) changes, retinopathy and nephropathy (p<0.0001).

Conclusions: Early identification of thyroid dysfunction and correction of thyroid function may result in better glycerin control and help prevent the development of long-term complications.

 

Author Biography

Jayant K. Golwalkar, Department of General Medicine, Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari, Maharashtra, India

Associate Professor,

Department of General Medicine,

Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari.

References

Khurana, Ashok, Dhoat P, Jain G. Prevalence of thyroid disorders in patients of type 2 diabetes mellitus. Journal, Indian Academy of Clinical Medicine. 2016;17(1):12-15.

Palma CC, Pavesi M, Nogueira VG, Clemente EL, Vasconcellos Mde F, Pereira LC Júnior, et al. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol Metab Syndr. 2013;5:58.

Feely J, Isles TE. Screening for thyroid dysfunction in diabetics. Br Med J. 1979;1:1678.

Umpierrez GE, Latif KA, Murphy MB, Lambeth HC, Stentz F, Bush A, et al. Thyroid dysfunction in patients with type 1 diabetes: A longitudinal study. Diabetes Care. 2003;26:1181-5.

Kadiyala R, Peter R, Okasieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. International Journal of Clinical Practice. 2010;64:1130-39.

Brenta G. Diabetes and thyroid disorders. British Journal of Diabetes and Vascular Disease. 2010;10:172-77.

American diabetes association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010;33:562-9.

Sugure DD, McEvoy M, Drury MI. Thyroid disease in diabetics. Postgrad Med J. 1999;91(1):680-4.

Gray RS, Irvine WJ, Clarke BF. Screening for thyroid dysfunction in diabetics. Br Med J. 1979;2(6202):1439.

Swamy RM, Kumar N, Shrinivasa K, Manjunath GN, Prasad Bhagav DS, Venatesh G. Evaluation of hypothyroidism as a complication in Type 2 Diabetes Mellitus. Biochemical Research. 2012;23(2):170-72.

Ahmed A. Assessment of Thyroid Dysfunctions in Type 2 Diabetes Mellitus Patients in Surman, Western-Libya. International Journal of Clinical and Experimental Medical Sciences. 2017;3(1):1-4.

Elmenshawi IM, Alotaibi SS, Alazmi AS, Alazmi AM, Alruwaili FR. Prevalence of Thyroid Dysfunction in Diabetic Patients. J Diabetes Metab Disord Control. 2017;4(2):00106.

Raval. Correlation between Hypothyroidism and Diabetes – A Hospital based Study. International Journal of Contemporary Medical Research. 2017;4(1):77-83.

Cho JH, Kim HJ, Lee JH, Park R, Moon SJ, Yoon SJ et al. Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus. The Korean Journal of Internal Medicine. 2016;31(4):703-11.

Pasupathi P, Bhakthavatsalam G, Saravanan G, Sundarmurthy R. Screening for Thyroid Dysfunction in Diabetic /Non diabetic population. Thyroid Science. 2008;3(8):CLS 1-6.

Ogbonna SU, Ezeani IU, Okafor CI, Chinenye S. Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus. Diabetes, metabolic syndrome and obesity: targets and therapy. 2019;12:1113.

Brahme K. Does the glycemic control and duration of diabetes affect Thyroid Dysfunction? A cross-sectional study from a tertiary hospital in Central Gujarat. Sch J App Med Sci. 2016;4(8D):3031-36.

Sreelatha, Madavaram. Study of thyroid profile in patients with type 2 diabetes mellitus. International Journal of Scientific Study. 2010;5(2):211-20.

GA Mohamed, AM Elsayed. Subclinical hypothyroidism ups the risk of vascular complications in type 2 diabetes /Alexandria Journal of Medicine. 2017;53:285-88.

George S. A Study on Prevalence of Co-Morbidities among Hypothyroidism Patients in Various Hospitals- Palakkad. Ijppr Human. 2017;9(3):225-33.

Kim. Association between subclinical hypothyroidism & severe diabetic retinopathy in Korean patients with type 2 diabetes. Endocrinology journal. 2011;58(12):1065-70.

Jingyang Wu, Yue S, Geng J, Liu L, Teng W, Liu L et al. Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis. Scientific reports. 2015;12212.

Qi Q. Association between TSH with microvascular complications in type 2 diabetic patients. Med Sci Monit. 2017;23:2715-20.

Zhou Z. Subclinical hypothyroidism & the risk of chronic kidney disease in T2D subjects. Medicine. 2017;96:15(e6519).

Furukawa. Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus. Japan Endocrine Journal. 2014;61(10):1011-8.

Downloads

Published

2020-12-22

Issue

Section

Original Research Articles