Systemic sclerosis: a rare presentation


  • Elvi Aprillia Karamoy Department of Internal Medicine, Wangaya Regional General Hospital, Denpasar, Bali, Indonesia
  • Jason Raymond Hotama Department of Internal Medicine, Wangaya Regional General Hospital, Denpasar, Bali, Indonesia
  • Ketut Suryana Department of Internal Medicine, Wangaya Regional General Hospital, Denpasar, Bali, Indonesia
  • Novitasari . Department of Anatomical Pathology, Wangaya Regional General Hospital, Denpasar, Bali, Indonesia



Systemic sclerosis, Scleroderma, Sclerodactyly, Skin thickening, Autoimmune


Systemic sclerosis or so called scleroderma is an uncommon autoimmune inflammatory and fibrotic connective tissue disease involving multiple organs. The etiology of systemic sclerosis is currently unknown and its pathogenesis is only partially understood. Skin thickening and Raynaud’s phenomenon are the most common symptoms. Although systemic sclerosis is uncommon, it is associated with high morbidity and mortality. In this report, we present a case of a-43-year-old man with the complaint of weakness, tightening of the skin over the fingers, tingling in the soles of feet, nausea and significant weight loss. Laboratory examinations revealed positive ANA test, but negative anti topoisomerase I (anti-Scl-70), and anticentromere antibody.


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