Thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus: a cross-sectional study

Manouchehr Iranparvar, Hosein Ghorbani, Ahad Azami, Hosein Darvishkhah


Background: Objective of current to investigate the relation between Thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus (GDM).

Methods: This is a cross-sectional descriptive study. In this study, 70 pregnant women in the third trimester of pregnancy with GDM (case group) and 70 healthy pregnant women in the same way (control group) were enrolled. Thyroid function tests (including serum TSH, fT4 level) and anti-TPO auto antibodies were measured in all women. Family history of the diabetes mellitus, GDM and thyroid disease was determined in both groups. Information of all patients was entered in checklists and then analyzed by statistical methods in SPSS.19.

Results: The mean age of patients in case group was 29.98±6.23 and in control group was 28.38 ±6.15. In cases 27.1 % have family history of type 2 diabetes, 2% have history of thyroiditis disorder and 7.1% have history of gestational diabetes. The mean of BMI in cases with 30.52 was more than controls with 29.58. Obtained data showed that TSH level (p=0.033) and anti- TPO (p=0.001) in cases were more than controls and FT4 (p=0.001) level was lower.   

Conclusions: The results showed that thyroid disorders in pregnancy women with gestational diabetes were significantly more than control group. So, doing necessary thyroid function tests as routinely was recommended. 


Pregnancy, Thyroid dysfunction, Gestational diabetes, Diabetes type 2

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