A prospective study of clinical pattern of febrile thrombocytopenia in government general hospital, Nalgonda
DOI:
https://doi.org/10.18203/2349-3933.ijam20210268Keywords:
Dengue, Elisa, Febrile, Hepatitis, Myalgia, Nausea, ThrombocytopeniaAbstract
Background: Febrile thrombocytopenia is a usual condition caused by infections such as dengue, malaria, typhoid, septicimea and certain viral infections. The present study is aimed to study the aetiology of fever with thrombocytopenia and the clinical presentation in the patients admitted in Government General Hospital.
Methods: This prospective observational study was done from August 2019 to September 2019 in Government General Hospital Nalgonda. A total of 100 cases male and female admitted with febrile thrombocytopenia were studied based on inclusion and exclusion criteria. All patients were done routine investigations and ELISA test for dengue done in susceptible patients. Patients below 12 years, pregnant women and patients with previous bleeding manifestations were excluded from the study. The study was carried out in all patients fulfilling the inclusion and exclusion criteria.
Results: A total of 100 patients 60 females and 40 males presented during the study period. Most of the fevers with low platelet count were viral 30 (30%), dengue 25 (25%), typhoid 20(20%), malaria 15 (15%), hepatitis 10 (10%). The patients presented with fever 25 (25%), nausea 20 (20%), headache 20 (20%) abdominal ain 15 (15%), diarrhea 10 (10%), bleeding manifestations 5 (5%), myalgia 5 (5%).
Conclusions: It was observed from the study that the viral infections were predominant cause for the fevers with thrombocytopenia followed by dengue, typhoid and malaria, furthur it was observed that apart from fever nausea and headache were predominant symptoms in patients presenting with febrile thrombocytopenia. Major complications were avoided by timely admission and proper care of the patients.
References
Larson EB, Featherstone HJ, Peterfdorf RG. Fever of undetermined origin. Diagnosis and Follow up of 105 cases, 1970-1980. Medicine 1982;61:269-92.
Lee TL, Stitt JT. Disorders of temperature regulation. Compr Ther. 1995;21:697.
Nolan SM, Fitzgerald FD. Fever of unknown origin-The general Internist’s approach. Postgraduate Med. 1987;81(5):190-205.
Mackowiak PA, Wasserman SS, Levine MM. A critical appraisal of 98.6 degrees F, the upper limit of the normal body temperature, and other legacies of Carl Reinhold August Wunderlich. J Am Med Asso. 1992;268:1578.
Patil P, Solanke P, Harshe G. To study clinical evaluation and outcome of patients with febrile thrombocytopenia. Int J Sci Applied Res. 2014;4(10):1-3.
Kumar A, Aster. Robbins and cotran pathologic basis of disease. 8th edition. Elsevier Health Sciences Division. 2010:687.
Levine SP. Wintrobe’s Clinical Haematology. 10th ed. Philadelphia Lippincott Williams and Wilkins Publishers. 1993:1579-1632.
Colman RW, Hirsch J, Marder VJ, Salzman EW. Hemostasis and thrombosis-basic principles and clinical practice. Philadelphia: Lippincott Williams and Wilkins. 1982:246-247.
Gondhali MP, Vethekar GM, Bhangale D, Choudhary K, Chaudhary M, Patrike G, Kundgir A. Clinical assessment of fever with thrombocytopenia - a prospective study. Int J Med Res Health Sci. 2016;5(1):258-77.
Durbesula AT, Reddy CKB, Usham G, Durbesula RK. Clinical profile of fever with thrombocytopenia in tertiary hospital, Nellore. J Med Sci Clin Res. 2016;4(9):12595-601.
Modi TN, Mehta AD, Santosh A, Modi S. Clinical profile of febrile thrombocytopenia: a hospital-based cross-sectional study. J Res Med Dental Sci. 2016;4(2):115-20.
Patil P, Solanke P, Harshe G. To study clinical evaluation and outcome of patients with febrile thrombocytopenia. Int J Scientific Res. 2014;4:1-3.
Nakhale BD, Bhagat JP, Dube AH. Study of febrile thrombocytopenia in adults. Int J Recent Trends Sci Tech. 2016;18(1):197-201.
Kumar P, Chandra K. A clinical study of febril thrombocytopenia: a hospital based retrospective study. Indian J Clin Practice. 2014;24(10):952-7.
Kumbhar SS. A Study of clinical and laboratory profile of patients having fever with thrombocytopenia and its outcome. Indian J Basic Applied Med Res. 2017;6(2):282-9.
Raikar S, Kamdar P, Dabhi A. Clinical and laboratory evaluation of patients with fever with thrombocytopenia. Indian J Clin Practice. 2013;24:360-2.