Acute aortic thrombosis as a presenting feature of COVID-19: case report and review of literature

Authors

  • Chitralekha A. Nayak Department of Medicine, Healthway Hospitals, Goa
  • Oscar Rebello Department of Medicine, Healthway Hospitals, Goa
  • Noel Britto Department of Anaesthesia, Healthway Hospitals, Goa
  • Gaurav Sardesai Department of Radiodiagnosis, Healthway Hospitals, Goa
  • Ajeya Mundhekar Department of Cardiology, Healthway Hospitals, Goa

DOI:

https://doi.org/10.18203/2349-3933.ijam20210084

Keywords:

Aortic thrombosis, COVID-19, Paraplegia, D-dimer

Abstract

Acute aortic thrombosis is an uncommon vascular emergency that can present with neurologic symptoms like acute paraplegia due to spinal cord ischemia. It frequently causes mortality unless appropriate diagnosis is followed immediately by proper management. Individuals with COVID-19 have coagulopathy with hyper inflammatory response which predisposes to both venous and arterial thrombotic events, especially in severe patients. We report a rare case of 63-year-old COVID-19 patient presenting as acute flaccid paraplegia with hematuria secondary to acute extensive aortic thrombus. CT scan showed bilateral COVID-19 pneumonia inspite of absence of respiratory symptoms. All patients with thrombotic events should be investigated for COVID-19 pneumonia as patients may not have typical respiratory symptoms.  

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Author Biographies

Chitralekha A. Nayak, Department of Medicine, Healthway Hospitals, Goa

Consultant Physician,

Department of Medicine,

Healthway Hospital,

Goa, India

Oscar Rebello, Department of Medicine, Healthway Hospitals, Goa

Consultant Physician,

Department of Medicine,

Healthway Hospital,

Goa, India

Noel Britto, Department of Anaesthesia, Healthway Hospitals, Goa

Consultant Anaesthesiologist and intensivist,

Department of Anaesthesia,

Healthway Hospital,

Goa, India

Gaurav Sardesai, Department of Radiodiagnosis, Healthway Hospitals, Goa

Consultant Radiologist,

Department of Radiodiagnosis,

Healthway Hospital,

Goa, India

Ajeya Mundhekar, Department of Cardiology, Healthway Hospitals, Goa

Consultant Cardiologist,

Department of Cardiology,

Healthway Hospital,

Goa, India

References

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506.

Carod-Artal FJ. Neurological complications of Coronavirus and COVID-19. Rev Neurol. 2020;70(9):311-22.

Xiong TY, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J 2020;41(19):1798-800.

Klok FA, Kruip MJ, Van der Meer NJ, Arbous MS, Gommers DA, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombos Res. 2020.

Le Berre A, Marteau V, Emmerich J, Zins M. Concomitant acute aortic thrombosis and pulmonary embolism complicating COVID-19 pneumonia. Diagn Interv Imag. 2020;101(5):321-2.

Saif MW, Greenberg B. HIV and thrombosis: a review. AIDS Pat Care STDS. 2001;15(1):15-24.

Mosbahi S, Heinisch PP, Schoenhoff FS, Berger DC. COVID-19-associated aortic arch thrombus. Eur J Cardiothorac Surg. 2020;58:870.

Dossa CD, Shepard AD, Reddy DJ, Jones CM, Elliott JP, Smith RF, et al. Acute aortic occlusion: a 40-year experience. Arch Surg. 1994;129:603-8.

Crawford JD, Perrone KH, Wong VW, Mitchell EL, Azarbal AF, Liem TK, et al. A modern series of acute aortic occlusion. J Vasc Surg. 2014;59:1044-50.

Guan W, Ni Z, Hu Y, Liang WH, Ou CG, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708-20.

Han H, Yang L, Liu R, Liu F, Wu KL, Li J, Liu XH, Zhu CL. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinic Chem Lab Med. 2020.

Bompard F, Monnier H, Saab I, Tordjman M, Abdoul H, Fournier L, et al. Pulmonary embolism in patients with Covid-19 pneumonia. Europ Respirat J. 2020.

Kashi M, Jacquin A, Dakhil B, et al. Severe arterial thrombosis associated with COVID-19 infection. Thromb Res. 2020;192:75-7.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020.

Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020.

Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, et al. Coagulopathy and antiphospholipid antibodies in patients with Covid-19. N Engl J Med. 2020;382:e38.

Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020;18:1094-9.

Varga Z, Flammer AJ, Steiger P et al. Endothelial cell infection and endothelitis in COVID-19. Lancet. 2020;395(10234):1417-8.

McGonagle D, Sharif K, O’Regan A, Bridgewood C. The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun Rev. 2020;19:10253.

Frantzeskaki F, Armaganidis A, Orfanos SE. Immunothrombosis in acute respiratory distress syndrome: cross talks between inflammation and coagulation. Respiration. 2017;93(3):212-25.

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Published

2021-01-27

How to Cite

Nayak, C. A., Rebello, O., Britto, N., Sardesai, G., & Mundhekar, A. (2021). Acute aortic thrombosis as a presenting feature of COVID-19: case report and review of literature. International Journal of Advances in Medicine, 8(2), 266–269. https://doi.org/10.18203/2349-3933.ijam20210084

Issue

Section

Case Reports