DOI: http://dx.doi.org/10.18203/2349-3933.ijam20151012

Association of type ii diabetes mellitus with pulmonary tuberculosis: a clinical and radiological study

Jahnavi K, Mallikarjuna Reddy C., Swetha Madas, Hima Bindu M.

Abstract


Background: The link between diabetes mellitus and tuberculosis has been recognized for centuries. It is only in the later years that the association has been identified. Diabetes mellitus has been reported to modify the presenting features of pulmonary tuberculosis, but there are varying data, particularly regarding the association with lower lung field involvement.  

Methods: 229 pulmonary/pleural fluid TB positive patients were tested for presence of type II diabetes. Clinical and radiological tests were done and analyzed for all patients.  

Results: 109 of 229 patients were diabetic and more than 50% of them were males. The most common symptoms were loss of appetite and weight, followed by cough and fever. Mixed zone involvement of the lung was a more common presentation than upper or lower zone.

Conclusions: We have tried to highlight the importance of Diabetes mellitus as a potential risk factor for Pulmonary tuberculosis patients, especially in the geographical regions were the two diseases are highly prevalent. More studies need to be performed in a region to establish the association between the two. 


Keywords


Diabetes mellitus, Pulmonary tuberculosis, Clinical findings, Radiological study

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References


Dennis L. Kasper, Eugene Braunwald, Stephen Hauser, Dan Longo, J. Larry Jameson, Anthony S. Fauci. Alvin diabetes mellitus. In: Dennis L. Kasper, Eugene Braunwald, Stephen Hauser, Dan Longo, J. Larry Jameson, Anthony S. Fauci, eds. Harrison’s Principles of Internal Medicine. 16th ed. New York, NY: McGraw Hill Publishers; 2005: 953-965, 2153-2180.

King H, Aubert RE, Herman WH. Global Burden of Diabetes 1995-2025: prevalence, numerical estimates and projections. Diabetes Care. 1998;21:1414.

Malin AS, McAdam KPWJ. Escalating threat from tuberculosis: the third epidemic. Thorax. 1995;50:37.

Amrit Guptan, Ashok Shah. Tuberculosis and diabetes: an appraisal. Indian J Tuberc. 2000;47:3.

Stevenson CR, Critchley JA, Forouhi NG, Roglic G, Williams BG, Dye C, et al. Diabetes and the risk of tuberculosis: a neglected threat to public health? Chronic Illn. 2007;3:228-45.

Sidibé el H. Pulmonary tuberculosis and diabetes: aspects of its epidemiology, pathophysiology, and symptoms. Sante. 2007 Jan-Mar;17(1):29-32.

Bachti Alisjahbana, Edhyana Sahiratmadja, Erni J. Nelwan, Anugrah Maya Purwa, Yana Ahmad, Tom H. M. Ottenhoff, et al. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin Infect Dis. 2007;45:428-35.

Caron Walker, Nigel Unwin. Estimates of the impact of diabetes on the incidence of pulmonary tuberculosis in different ethnic groups in England; Thorax. 2010;65:578-81.

Daniel Faurholt-Jepsen, Nyagosya Range, George PrayGod, Kidola Jeremiah, Maria Faurholt-Jepsen, Martine G. Aabye, et al. The role of diabetes on the clinical manifestations of pulmonary tuberculosis. Trop Med Int Health. 2012;17(7):877-83.

V. V. Banu Rekha, Rani Balasubramanian, Soumya Swaminathan, Rajeswari Ramachandran Fathima Rahman, V. Sundaram, K. Thyagarajan, et al. Sputum conversion at the end of intensive phase of Category-1 regimen in the treatment of pulmonary tuberculosis patients with diabetes mellitus or HIV infection: an analysis of risk factors. Indian J Med Res. 2007;126:452-8.

Golsha R, Shirazi RR, Shafiee A, Najafi L, Dasthi M, Roshandel G. Pulmonary tuberculosis and some underlying conditions in Golestan Province of Iran, during 2001-2005. JCDR. 2009;3(1):1302-6.

Stevenson CR, Critchley AJ, Fourohi GN. Diabetes and risk of tuberculosis a neglected threat to public health. Chronic Illn. 2007;3(3):228-45.

Gupta SK, Singh Z, Purty AJ, Vishwanathan M. Diabetes prevalence and its risk factors in urban Puducherry. Int J Diabetes Dev Ctries. 2009;29:166-9.

Bharati DR, Pal R, Kar S, Rekha R, Yamuna TV, Basu M. Prevalence and determinants of diabetes mellitus in Puducherry, South India. J Pharm Bioallied Sci. 2011;3:513-8.

Majgi SM, Soudarssanane BM, Roy G, Das AK. Risk factors of diabetes mellitus in rural Puducherry. Online J Health Allied Sci. 2012;11:4.

Soundararajan Raghuraman, Kavita P. Vasudevan, S. Govindarajan, Palanivel Chinnakali, Krishna Chandra Panigrahi. Prevalence of diabetes mellitus among tuberculosis patients in Urban Puducherry. N Am J Med Sci. 2014;6(1):30-4.

Roghieh G, Elham G, Rahim RS, Hamid G, Aida M. Diabetes mellitus and pulmonary tuberculosis, association or co-incidence? Pak J Med Sci. 2011;27(4):819-22.