Asthma related to gastroesophageal reflux disease: a case report and review
DOI:
https://doi.org/10.18203/2349-3933.ijam20211063Keywords:
Asthma, Gastroesophageal reflux disease, Pulmonary functionAbstract
Asthma is a common respiratory disorder that characterized by airway hyper-reactivity and chronic inflammation. Asthma and gastroesophageal reflux disease can occur together, both can affect each other. We represent 41 years old male patient with chief complaint of asthma that preceded burning sensation on his throat and also heartburn over the last three months. Patient had visited his family doctor but his symptom still occurred. He had been experienced six episodes of these symptoms since three month ago. On physical examination there were wheezing both of his lung and prolong expiration phase. There was no abnormality on the electrocardiogram, chest X-ray and complete blood count. After administration of short acting bronchodilator and proton pump inhibitor agent, patient clinical status improved dramatically. Patient than given salmoterol fluticasone inhaler, antacid, ANT proton pump inhibitor as take-home medication. On his follow up visit to policlinic on first, fourth- and eight-week patient denied any shortness of breath and heartburn anymore. Various pathological processes play a role in the pathogenesis of GERD and Asthma. There were two theories that suggested in the mechanism that caused GERD induced Asthma, including reflux and reflex theory.
References
Stern J, Pier J, Litonjua A. Asthma epidemiology and risk factors. Sem Immunopathol. 2020;42(1):5-15.
Tay R, Hew M. Comorbid “treatable traits” in difficult asthma: Current evidence and clinical evaluation. Allergy. 2018:73(7):1369-82.
So Y, Hye-Rim K, Chanyang M. Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort. Pediatr Res. 2020:88(2):320-4.
Broers C, Tack J, Pauwels A. Review article: gastro-oesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Aliment Pharmacol Therap. 2017;47(2):176-91.
Global strategy for asthma management and prevention, 2020. Available at: www.ginasthma.or. Accessed on 20 December 2020.
Thakkar K, Boatright R, Gilger M, El-Serag H. Gastroesophageal reflux and asthma in children: a systematic review. Pediatr. 2010;125(4):e925-30.
Bor S, Kitapcioglu G, Solak Z, Ertilav M, Erdinc M. Prevalence of gastroesophageal reflux disease in patients with asthma and chronic obstructive pulmonary disease. J Gastroenterol Hepatol. 2010;25 (2):309-13.
Bush A. Pathophysiological mechanisms of asthma. Front Pediatr. 2019;7:68.
Kudo M, Ishigatsubo Y, Aoki I. Pathology of asthma. Front Microbiol. 2013;4:263
Jack C, Calverley P, Donnelly R. Simultaneous trachealand oesophageal pH measurements in asthmatic patients with gastrooesophageal reflux. Thorax.1995;50:201-4.
Pauwels A, Decraene, Blondeau K. Bile acids in sputum and increased airway inflammation in patients with cystic fibrosis. Chest. 2012;141:1568-74.
Naik R. Extra-esophageal manifestations of GERD: who responds to GERD therapy?. Curr Gastroenterol Rep. 2013;15(4):318.
Gaude S, Karanji J. Gastro-esophageal reflux disease in bronchial asthma-Is there anassociation. Int J Basic Appl Med Sci. 2012;2(1):179-90.
Heidelbaugh J, Gill, A., Van H. Atypical presentations of gastroesophageal refluxdisease. Am Family Physic. 2008;78(4):483-8.
Ates F, Vaezi MF. InsightInto the relationship between gastroesophageal reflux disease and asthma. Gastroenterol Hepatol. 2014;10:729-36.
Crowell D, Zayat N, Lacy E. The effects of an inhaled beta adrenergic agonist on lower esophageal function: a dose response study. Chest. 2001;120(4):1184-9.