Blood biochemical abnormalities of intensive care unit patients with SARS-CoV-2 infection, single center experience in Bangladesh


  • Bidoura Naznin Pathology and Laboratory Medicine, Square Hospitals Limited, Dhaka, Bangladesh
  • Mousumi Ghosh Pathology and Laboratory Medicine, Square Hospitals Limited, Dhaka, Bangladesh
  • Raihan Rabbani Internal Medicine and ICU, Square Hospitals Limited, Dhaka, Bangladesh
  • Israt Yesmin Pathology and Laboratory Medicine, Square Hospitals Limited, Dhaka, Bangladesh
  • Arebia Rahman Pathology and Laboratory Medicine, Square Hospitals Limited, Dhaka, Bangladesh



Biochemical, SARS-CoV-2, ICU, COVID-19


Background: Since its emergence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and led to ever-increasing mortality. SARS-CoV-2 infection perturbs the function of the body’s vital organs, making patients of all ages susceptible to the disease. Nevertheless, individuals developing critical illness with poor outcomes were mostly the elderly and people with co-morbid conditions, who constituted the vast majority of coronavirus disease 2019 (COVID-19) fatalities. Complications of COVID-19 mostly involve the respiratory, renal and cardiovascular systems, and in severe cases secondary infections leading to pneumonia and acute respiratory distress syndrome, which may precede the death of the patient. Multi-organ failure in individuals with COVID-19 could be a consequence of their co-morbidities. It is hoped that the review will lead to more comprehensive understanding of this complex disease. The aim of the study was to evaluate biochemical abnormalities during SARS-CoV-2 infection of ICU patients.

Methods:This observational study was conducted in Square Hospital Limited, Dhaka, Bangladesh, on 50 patients received ICU treatment with moderate to severe COVID-19 symptoms admitted to this hospital from 15 July to 15 September 2020.

Results: Among the participants most of them were 19 (38%) belongs to 65-74 years age group male 38 (78.00%) were dominating the gender distribution. IL6, CRP, creatinine and troponin were found the most significant in biochemical blood parameters. The maximum level of comorbidity was observed due to diabetes mellitus, ischemic heart disease, and hypertension.

Conclusions:Biochemical parameters may be used as an indicator of COVID-19 infections and the severity of ICU patients. For the consistency of the course of patients, the markers could be used.


Gorbalenya AE, Baker SC, Baric RS, Groot RJ, Drosten C, et al. Severe acute respiratory syndrome-related coronavirus: The speciesand its viruses–a statement of the Coronavirus Study Group. BioRix. 2020.

Chan JW, Ng CK, Chan YH, Mok TY, Lee S, Chu SY, et al. Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS). Thorax. 2003;58(8):686-9.

Booth TF, Kournikakis B, Bastien N, Ho J, Kobasa D, Stadnyk L, et al. Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units. J Infect Dis. 2005;191(9):1472-7.

Cascella M, Rajnik M, Aleem A, Dulebohn HC, Napoli RD. Features, Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls. 2021.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Remuzzi A, Remuzzi G. COVID-19 and Italy: what next?. Lancet. 2020;395(10231):1225-8.

Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-8.

Fan BE, Chong VCL, Chan SSW, Lim GH, Lim KGE, Tan GB, et al. Hematologic parameters in patients with COVID-19 infection. Am J Hematol. 2020;95(6):131-4.

Wang JT, Sheng WH, Fang CT, Chen YC, Wang JL, Yu CJ, et al. Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients. Emerg Infect Dis. 2004;10(5):818-24.

Qu R, Ling Y, Zhang YH, Wei LY, Chen X, Li XM, et al. Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol. 2020;92(9):1533-41.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13.

Ye Q, Wang B, Mao J. The pathogenesis and treatment of the `Cytokine Storm' in COVID-19. J Infect. 2020;80(6):607-13.

Aziz M, Fatima R, Assaly R. Elevated interleukin-6 and severe COVID-19: A meta-analysis. J Med Virol. 2020; 92(11):2283-5.

Gao Y, Li T, Han M, Li X, Wu D, Xu Y, Zhu Y, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;92(7):791-6.

Outschoorn UE, Prisco M, Ertel A, Tsirigos A, Lin Z, Pavlides S, et al. Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle. 2011;10(8):1271-86.

Zhang G, Zhang J, Wang B, Zhu X, Wang Q, Qiu S. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis. Respir Res. 2020;21(1):74.

Cervellin G, Schuetz P, Lippi G. Toward a holistic approach for diagnosing sepsis in the emergency department. Adv Clin Chem. 2019;92:201-16.

Schuetz P, Albrich W, Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Med. 2011;9:107.

Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020;58(7):1131-4.

Lala A, Johnson KW, Russak AJ. Prevalence and Impact of Myocardial Injury in Patients Hospitalized with COVID-19 Infection. Preprint. medRxiv. 2020; 2020.

Ni W, Yang X, Liu J, Bao J, Li R, Xu Y, et al. Acute Myocardial Injury at Hospital Admission Is Associated With All-Cause Mortality in COVID-19. J Am Coll Cardiol. 2020;76(1):124-5.






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