Impact of alcohol on gastric mucosa in a population with high prevalence of Helicobacter pylori

Sultan Nawahir; George Kurian; Thomas Alexander; Susy Kurian

doi:10.18203/2349-3933.ijam20212096

Authors

Sultan Nawahir Department of Gastroenterology, Chettinad Health City, Kelambakkam, Tamil Nadu, India http://orcid.org/0000-0002-2484-5433
George Kurian Department of Gastroenterology, Pondicherry Institute of Medical Sciences, Pondicherry, India
Thomas Alexander Department of Gastroenterology, Pondicherry Institute of Medical Sciences, Pondicherry, India
Susy Kurian Department of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20212096

Keywords:

Atrophic gastritis, Intestinal metaplasia, Gastric cancer

Abstract

Background: The purpose of the study was to see whether chronic alcohol abuse had any effect on the gastric mucosa in a population already affected by a high prevalence of Helicobacter pylori.

Methods: 35 males with a history of chronic alcohol abuse were compared with 35 males who were abstinent or social drinkers. All subjects had complaints of dyspepsia. All subjects underwent endoscopy and targeted biopsies were taken from three specific sites in the stomach, namely body, antrum and incisura. Biopsies were studied to look for changes of atrophic gastritis and intestinal metaplasia. The presence or absences of H. pylori on the tissue biopsy were also recorded.

Results: Atrophic gastritis were only assessable in 24 alcoholic patients and 21 non-alcoholic patients due to the inadequacy of the depth of the biopsy. AG were found to be equally distributed in both the groups. 23 (64.9%) patients in the alcoholic group and 19(54.5%) in the control group had AG (OR-1.54, p=0.47). Intestinal metaplasia was seen in 10 (28.5%) alcoholic group and 12 (34.2) in the control group (OR-0.65, p=0.45). Of the 42 subjects detected to have AG, 16 (38.1%) had IM. However, IM were always associated with AG. In addition, H. pylori were not seen to be different in the two groups. H. pylori were positive in 18 (51.4%) alcoholic and14 (40%) non-alcoholic patients (p=0.33).

Conclusions: Chronic alcohol abuse doesn’t appear to have any major impact on the gastric mucosa in terms of producing premalignant lesions such as atrophic gastritis or intestinal metaplasia or enhancing the prevalence of H. pylori.

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