DOI: http://dx.doi.org/10.18203/2349-3933.ijam20212105

Clinical profile and outcomes of patients with acute pancreatitis and correlation with severity index from a tertiary care centre in South India-retrospective analysis

Sultan Nawahir, Babu Kumar S., Bala Kasi Naik, Ealai Athmarao Parthasarathy

Abstract


Background: Acute pancreatitis is an inflammatory condition of the pancreas having a varied clinical presentation. It is one of the commonest causes of abdominal pain requiring hospital admission. This retrospective study aims to describe the clinical profile and outcomes of patients with acute pancreatitis and its correlation with severity index.

Methods: All patients admitted with a diagnosis of acute pancreatitis to medical gastroenterology department between January 2018 to December 2020 were included in this retrospective study.

Results: A total of 61 subjects were included in the final analysis. The mean age was 41.64, the ranged between 19 to 88 years. Among the study population, 53 (86.89%) were male and 8 (13.11%) were female. Among the people 43 (70.49%) were alcoholics, 22 (36.07%) were smokers, 11(18.03%) had systemic hypertension and 5 (8.20%) participants had type 2 diabetic mellitus. The mean CTSI was 2.15±2.82, the mean Balthazar was 3.43±2.4 and the mean procalcitonin was 2.52±9.28. The mean Lipase was 7822. There was a weak positive correlation between CTSI and CRP (rs value: 0.147, p=0.260). There was a weak negative correlation between Balthazar and CRP (rs value:-0.067, p=0.606).

Conclusions: Among the study population, 87% of the patients were males. 70% of the population were alcoholics. Mean serum lipase was 7822. There was a weak positive correlation between CTSI and CRP (rs value: 0.147, p=0.260). There was a weak negative correlation between Balthazar and CRP (rs value:-0.067, p=0.606).


Keywords


Acute pancreatitis, CTSI, Balthazar

Full Text:

PDF

References


Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Gregory G. Tsiotos, and Santhi Swaroop Vege. Classification of Acute Pancreatitis-2012: Revision of the Atlanta Classification and Definitions by International Consensus. Gut. 2013;62(1):102-11.

Vege SS, Gardner TB, Chari ST. Low mortality, and high morbidity in severe acute pancreatitis without organ failure: a case for revising the Atlanta classification to include moderately severe acute pancreatitis. Am J Gastroenterol. 2009;104:710-5.

Pancreatitis, India, Case Reports, Symptoms Treatment. Available at: https://www.omicsonline.org/india/pancreatitis-peer-reviewed-pdf-ppt-articles/. Accessed March 14, 2021.

Swaroop VS, Chari ST, Clain JE. Severe acute pancreatitis. JAMA. 2004;291:2865.

Banks PA. Acute pancreatitis: Diagnosis. In: Pancreatitis, Lankisch PG, Banks PA (Eds), Springer-Verlag, New York 1998;75.

Banks PA, Freeman ML. Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006;101:2379.

Roberts SE, Morrison-Rees S, John A, Williams JG, Brown T, Samuel DG. The incidence and aetiology of acute pancreatitis across Europe. Pancreatol. 2017;2:155e165.

Apte MV, Wilson JS, McCaughan GW. Ethanol-induced alterations in messenger RNA levels correlate with glandular content of pancreatic enzymes. J Lab Clin Med. 1995;125:634.

Aune D, Mahamat-Saleh Y, Norat T, Riboli E. Tobacco smoking and the risk of pancreatitis: A systematic review and meta-analysis of prospective studies. Pancreatology. 2019;19:1009.

Yadav D, Agarwal N, Pitchumoni CS. A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol. 2002;97:1309.

Frank B, Gottlieb K. Amylase normal, lipase elevated: is it pancreatitis? A case series and review of the literature. Am J Gastroenterol. 1999;94:463.

Larvin M. Assessment of clinical severity and prognosis. In: The Pancreas, Beger HG, Warshaw AL, Buchler MW (Eds), Blackwell Science, Oxford. 1998;489.