A nationwide questionnaire-based survey on practice patterns and management of chronic stable angina with a controlled release formulation of trimetazidine


  • Anil Balachandran Department of Cardiology, Lakshmi Hospital, Kochi, Kerala, India
  • V. Jaganathan Heart Care Centre, Chennai, Tamil Nadu
  • Darshan Jhala Lilavati Hospital, Mumbai, Maharashtra, India
  • Sunandan Sikdar NH Narayana Hospital, Barasat, West Bengal, India
  • Darshan Jhala Lilavati Hospital, Mumbai, Maharashtra, India
  • Sunandan Sikdar NH Narayana Hospital, Barasat, West Bengal, India
  • Absar Ahmad Dr. Absar Ahmad Clinic, Moradabad, Uttar Pradesh, India




Chronic stable angina, Trimetazidine, Questionnaire-based survey


Background: There is lack of real-world evidence on various aspects of chronic stable angina (CSA). Hence, a questionnaire-based survey was conducted to garner real-world data about the prevalence of CSA among Indian patients; the associated comorbidities among these patients; management practices for CSA in India; and factors affecting compliance in patients with CSA with a special focus on day and night pack for trimetazidine controlled release (CR) 35 mg BD tablets.

Methods: In all, 100 health care practitioners (HCPs) who each observed 15 patients with CSA in their clinical practice participated in this quantitative, cross-sectional, questionnaire-based study. The data were collected using a structured questionnaire with 30 questions grouped into 5 sections. Data were analyzed using percentages.

Results: The results from the survey showed that 52.7% HCPs had observed 31-50% of angina patients with diabetes mellitus as comorbidity. As per the questionnaire survey, 77.4% HCPs preferred trimetazidine as a second-line agent when an angina patient was not responding to beta-blockers, calcium channel blockers (CCBs), and nitrates. Furthermore, 30.1% of HCPs preferred trimetazidine CR 35 mg BD as it improved exercise tolerance as well. Results from the survey reported that 65.6% HCPs agreed with the statement that day and night packs of trimetazidine tablets help in improving patient compliance and adherence to therapy.

Conclusions: Trimetazidine CR 35 mg BD appears to have a safety profile suitable for various conditions and for patients with multiple comorbidities. Trimetazidine day and night packs of tablets help in improving patient compliance and adherence to therapy.


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Original Research Articles