A study of the association of serum uric acid levels with alanine aminotransferase and gamma-glutamyl transferase levels in non-alcoholic fatty liver disease patients diagnosed by imaging studies


  • Anant Parasher Department of Medicine, Guru Teg Bahadur Hospital, New Delhi, India
  • Kunal Ranjan Department of Medicine, Guru Teg Bahadur Hospital, New Delhi, India




Cirrhosis, Hyperuricemia, Liver failure, Non-alcoholic fatty liver disease, Steatosis


Background: Non-alcoholic fatty liver disease (NAFLD) is a condition defined by excessive fat accumulation in the form of triglycerides (steatosis) in the liver. In recent years, an association between elevated serum uric acid concentrations and NAFLD has been reported. The aim of the study was to perform cross-sectional study to determine the association between serum uric acid levels and the levels of serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), in NAFLD patients.

Methods: In this hospital-based cross-sectional study, 300 patients with diagnosed NAFLD were included during the one-year period from July 2015 to June 2016.

Results: Elevation of alanine aminotransferase levels was seen in a total of 93 cases (31%) and elevation of GGT levels in NAFLD patients was seen in 112 patients out of a total of 300 (37.33%). Hyperuricemia was observed in 99 cases out of a total of 300 cases of NAFLD (33%). A significant association was observed between the two parameters.

Conclusions: The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83 %) (p<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (p<0.001). The relationship between rising uric acid levels with rising ALT and GGT levels in these patients was also found to be statistically significant.

Author Biographies

Anant Parasher, Department of Medicine, Guru Teg Bahadur Hospital, New Delhi, India

Medicine, Senior Resident

Kunal Ranjan, Department of Medicine, Guru Teg Bahadur Hospital, New Delhi, India

SR, Medicine


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Original Research Articles