Prevalence of asthma chronic obstructive pulmonary disease overlap in patients attending a tertiary health care centre
DOI:
https://doi.org/10.18203/2349-3933.ijam20212859Keywords:
ACO, Asthma, COPD, GINA, GOLDAbstract
Background: The study aimed to assess the magnitude of asthma chronic obstructive pulmonary disease asthma chronic obstructive (ACO) in patients with chronic airway disease.
Methods: The study was conducted as cross-sectional study on patients with chronic airway disease presenting at our institute during the study period of 1 year. Global initiative for asthma management and prevention (GINA) syndromic approach table was used to diagnose patients with chronic airways disease. Syndromic and confirmatory diagnosis of ACO was made based upon clinical features and spirometry respectively.
Results: About 73.6% were diagnosed as chronic obstructive pulmonary disease (COPD) and 26.4% cases were diagnosed as asthma. Overall ACO was present in 20% cases. ACO was significantly associated with advancing age, male gender, and longer duration of smoking (p<0.05) in asthma patients whereas in COPD patients ACO was associated with advancing age (p<0.05).
Conclusions: Overall one fifth of the patients with chronic airway disease have asthma COPD overlap. The ACO is observed in almost equal proportions in asthma and COPD. ACO prevalence was found to increase with age in patients with asthma and COPD.
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References
GINA Report 2017: Global Strategy for Asthma Management and Prevention. Available at: http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/. Accessed on 6th March 2021.
Global Initiative for Chronic Obstructive Lung Disease. Gold-COPD.org/wp‐content/uploads/2017/11/GOLD‐2018‐v6. 0‐FINAL‐revised‐20‐Nov_WMS. pdf. Accessed on 6th March 2021.
Cukic V, Lovre V, Dragisic D, Ustamujic A. Asthma and Chronic Obstructive Pulmonary Disease (COPD) - Differences and Similarities. Mater Sociomed. 2012;24(2):100-5.
Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology. 2006;11(1):54-61.
Hoenderdos K, Condliffe A. The neutrophil in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013;48(5):531-9.
Panettieri RA. Neutrophilic and pauci-immune phenotypes in severe asthma. Immunol Allergy Clin. 2016;36(3):569-79.
Postma DS, Boezen HM. Rationale for the Dutch hypothesis. Allergy and airway hyperresponsiveness as genetic factors and their interaction with environment in the development of asthma and COPD. Chest. 2004;126(2):96S-104.
Jo YS, Lee J, Yoon HI, Kim DK, Yoo C-G, Lee C-H. Different prevalence and clinical characteristics of asthma–chronic obstructive pulmonary disease overlap syndrome according to accepted criteria. Ann Allergy Asthma Immunol. 2017;118(6):696-703.
India State-Level Disease Burden Initiative CRD Collaborators. The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health. 2018;6(12):e1363-74.
Fu JJ, Gibson PG, Simpson JL, McDonald VM. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration. 2014;87(1):63-74.
Milanese M, Di Marco F, Corsico AG, Rolla G, Sposato B, Chieco-Bianchi F et al. Asthma control in elderly asthmatics. An Italian observational study. Respiratory med. 2014;108(8):1091-9.
Hosseini M, Almasi-Hashiani A, Sepidarkish M, Maroufizadeh S. Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis. Respiratory res. 2019;20(1):1-0.
Vaz Fragoso CA, Murphy TE, Agogo GO, Allore HG, McAvay GJ. Asthma-COPD overlap syndrome in the US: a prospective population-based analysis of patient-reported outcomes and health care utilization. Int J Chron Obstruct Pulmon Dis. 2017;12:517-27.
Kiljander T, Helin T, Venho K, Jaakkola A, Lehtimäki L. Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study. NPJ primary care respiratory med. 2015;25(1):1-5.
Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ et al. The clinical features of the overlap between COPD and asthma. Respiratory res. 2011;12(1):1-8.
Soriano JB, Davis KJ, Coleman B, Visick G, Mannino D, Pride NB. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest. 2003;124:474-81.
Montes de Oca M. Victorina Lopez Varela M, Laucho-Contreras ME, Casas A, Schiavi E, Mora JC. Asthma-COPD overlap syndrome (ACOS) in primary care of four Latin America countries: the PUMA study. BMC Pulm Med. 2017;17(1):69.
Park HJ, Byun MK, Kim HJ, Ahn CM, Lee JH, Shin KC et al. Asthma-COPD Overlap Shows Favorable Clinical Outcomes Compared to Pure COPD in a Korean COPD Cohort. Allergy Asthma Immunol Res. 2017;9(5):431-7.
Carpagnano GE, Lacedonia D, Malerba M, Palmiotti GA, Cotugno G, Carone M et al. Analysis of mitochondrial DNA alteration in new phenotype ACOS. BMC Pulm Med. 2016;12;16:31.
Cosío BG, Dacal D, Pérez de Llano L. Asthma-COPD overlap: identification and optimal treatment. Ther Adv Respir Dis. 2018;12:1753466618805662.