Published: 2021-07-23

Study of red cell distribution width levels and its correlation with severity of disease in patient with chronic obstructive pulmonary disease

Shashidhar Ramappa, Aishhwarrya Umeshchandra G., Sheshan V., Manigandan .


Background:COPD has been accepted as component of systemic inflammatory syndrome. Red cell distribution width (RDW) is a measure of coefficient of variation of mean corpuscular volume which increases in chronic systemic inflammation. The aim of the study was to evaluate the RDW as a predictor of severity of COPD using BODE index.

Methods:In this cross-sectional study 107 COPD patients were evaluated by measuring RDW and this was correlated with the severity of disease using GOLD staging.

Results:RDW correlates well with COPD patients. Significant correlation of RDW with BODE index (r=0.650, p and It; 0.001), gold staging (r=0.459, p and It; 0.001), 6MWT (r=0.697, p and It; 0.001) were observed.

Conclusions: RDW was found to increase in patients with increasing severity of COPD. Hence its potential role as a marker of severity of disease and in predicting risk of cardiovascular disease can be explored.


COPD, Red cell distribution width, GOLD staging

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Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet. 1997;349(9061):1269-76.

Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. Lancet. 1965;1(7389):775-9.

Snider GL, Kleinerman J, Thurlbeck WM, Bengali ZK. The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis. 1985;132(1):182-5.

Tertemiz KC, Ozgen AA, Sevinc C, Ellidokuz H, Acara AC, Cimrin A. Could "red cell distribution width" predict COPD severity?. Rev Port Pneumol. 2016;22(4):196-201.

Seyhan EC, Ozgul MA, Tutar N, Omur I, Uysal A, Altin S. Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease. COPD. 2013;10(4):416-24.

Sincer I, Zorlu A, Yilmaz MB, Dogan OT, Ege MR, Amioglu G, et al. Relationship between red cell distribution width and right ventricular dysfunction in patients with chronic obstructive pulmonary disease. Heart Lung. 2012;41(3):238-43.

Subhashree AR, Shanthi B, Parameaswari PJ. The red cell distribution width as a sensitive biomarker for assessing the pulmonary function in automobile welders- a cross sectional study. J Clin Diagn Res. 2013;7(1):89-92.

Ozgul G, Seyhan EC, Ozgul MA, Gunluoglu MZ. Red Blood Cell Distribution Width in Patients With Chronic Obstructive Pulmonary Disease and Healthy Subjects. Arch Bronconeumol. 2017;53(3):107-13.

Kurtoglu E, Akturk E, Korkmaz H, Sincer I, Yılmaz M, Erdem K, et al. Elevated red blood cell distribution width in healthy smokers. Turk Kardiyol Dern Ars. 2013;41(3):199-206.

Rahimirad S, Ghafari M, Ansarin K, Rashidi F, Rahimi RMH. Elevated red blood cell distribution width predicts mortality in acute exacerbation of COPD. Pneumologia. 2016;65(2):85-9.