Lipid profile: a conduit in the progression from psoriasis to cardiovascular disease

Samir Sahu, Ellora Devi, Anirban Poddar, Subhashree Ray


Background: Psoriasis although a disease of the skin has been reported to be associated with metabolic syndrome. Metabolic syndrome in turn is associated with dyslipidemia which is a independent risk factor for cardiovascular diseases. Our study therefore aims to assess lipid profile in patients with psoriasis with an objective to observe and report any significant deviations in the same as compared to healthy controls.

Methods: 25 patients with psoriasis and 25 age, sex matched healthy controls were recruited in this study and lipid profile was estimated using commercially available reagent kit which employs the CHOD-PAP method.

Results: Significant elevation in levels of total cholesterol, triglycerides, VLDL and cholesterol/HDL ratio was observed. Elevated although was observed in case of LDL and HDL levels, but it was statistically insignificant.

Conclusions: Dyslipidemia was found to be prevalent in psoriasis patients. Dyslipidemia is an independent risk factor for development of cardiovascular disease. Dyslipidemia in psoriasis therefore clearly suggests an inherent predisposition of psoriasis patients to suffer from cardiovascular diseases. A lipid profile estimation in these patients therefore might serve as an important tool for   risk assessment for cardiovascular disease, thereby aiding a timely intervention.


Dyslipidemia, Lipid profile, Psoriasis

Full Text:



Gelfand JM, Stern RS, Nijsten T, Feldman SR, Thomas J, Kist J, et al. The prevalence of psoriasis in African Americans-results from a population based study. J Am Acad Dermatol. 2005;52:23-6.

Pietrzak A, Stoma MA, Chodorowska G, Szepietowski JC. Lipiddisturbances in psoriasis: an update. Mediators Inflam. 2010;2010:13.

Mallbris L, Granath F, Hamsten A, Stahle M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol. 2006;54(4):614-21.

Akhyani M, Ehsani AH, Robati RM, Robati AM. The lipid profile inpsoriasis: a controlled study. J Eur Acad Dermatol Venerol 2007;21(10):1330-2.

Bedi TR. Clinical profile of psoriasis in North India. Indian J DermatolVenereal Leprol. 1995;61:202-5.

Dreiher J, Weitzman D, Davidovici B, Shapiro J, Cohen AD. Psoriasis and dyslipidemia: a population based study. Acta Derm Venerol. 2008;88:561-5

Pietrzak A, Lecewicz TB. Activity of serum lipase and the diversity of serum lipid profile in psoriasis. Med Sci Monit. 2002;8:9-13.

Frostegard J, Ulfgren AK, Nyberg P. Cytokine expression in advanced humana therosclerotic plagues: dominance of pro-inflammatory (Th1) and macrophages-stimulating cytokines atherosclerosis. 1999;145:33-43.

Pereira RP, Silva SA, Rebelo I, Figueiredo A, Quintani!ha A, Teixeira F. Dyslipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease. Clin Chim Acta. 2001;303(1):33-9.

Mallbris L, Granath F, Hamsten A, Stable M. Psoriasis is associated with lipid abnormalities at the onset of skin diseases. J Am acad Dermatol. 2006;54:614-21.