Lipid profile: a conduit in the progression from psoriasis to cardiovascular disease

Authors

  • Samir Sahu Department of General Medicine, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India
  • Ellora Devi Department of Physiology, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India
  • Anirban Poddar Department of Biochemistry IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India
  • Subhashree Ray Department of Biochemistry IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20170105

Keywords:

Dyslipidemia, Lipid profile, Psoriasis

Abstract

Background: Psoriasis although a disease of the skin has been reported to be associated with metabolic syndrome. Metabolic syndrome in turn is associated with dyslipidemia which is a independent risk factor for cardiovascular diseases. Our study therefore aims to assess lipid profile in patients with psoriasis with an objective to observe and report any significant deviations in the same as compared to healthy controls.

Methods: 25 patients with psoriasis and 25 age, sex matched healthy controls were recruited in this study and lipid profile was estimated using commercially available reagent kit which employs the CHOD-PAP method.

Results: Significant elevation in levels of total cholesterol, triglycerides, VLDL and cholesterol/HDL ratio was observed. Elevated although was observed in case of LDL and HDL levels, but it was statistically insignificant.

Conclusions: Dyslipidemia was found to be prevalent in psoriasis patients. Dyslipidemia is an independent risk factor for development of cardiovascular disease. Dyslipidemia in psoriasis therefore clearly suggests an inherent predisposition of psoriasis patients to suffer from cardiovascular diseases. A lipid profile estimation in these patients therefore might serve as an important tool for   risk assessment for cardiovascular disease, thereby aiding a timely intervention.

References

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Published

2017-01-23

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Section

Original Research Articles