DOI: http://dx.doi.org/10.18203/2349-3933.ijam20213248

Kikuchi-Fujimoto disease

Ashraf Alakkad, Mohamed Alakkad

Abstract


A lady from Sudan was referred to our medical clinic as a case of cervical lymphadenopathy with gradual enlargement. She had no complaint. The cervical lymphadenopathy was not associated with pain, fever, weight loss, cough, neither bleeding nor other associated swellings. There was no history of chronic medical problems including TB and underwent thorough investigations including LN biopsy. Lymphoma was initially suspected. Fine-needle aspiration and excision biopsy were undertaken. Histological analysis later suggested Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis. Kikuchi-Fujimoto disease (KFD) was described in 1972 as lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. KFD, frequently found in East Asian countries, is rare in the UK. No definite etiology of KFD is known despite autoimmune and infection factors being suggested. The diagnostic hallmark is histological findings from lymph nodes. Steroid therapy could be used in severe cases. KFD is relatively unknown and this case report aims to highlight its occurrence in our population.


Keywords


KFD, Histiocytic necrotizing lymphadenitis, Cervical lymphadenopathy

Full Text:

PDF

References


Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. Nippon Ketsueki Gakkai Zasshi. 1972;35:379-80.

Fujimoto Y, Kojima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological entity. Naika. 1972;20:920-7.

Lin HC, Su CY, Huang CC, CF Hwang, Chien CY. Kikuchi's disease: a review and analysis of 61 cases. Otolaryngology. 2003;128(5):650-3.

Hollingsworth HC, Peiper SC, Weiss LM, Raffeld M, Jaffe ES. An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease: lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents. Arch Pathol Lab Med. 1994;118(2):134-40.

Goldblatt F, Andrews J, Russell A, Isenberg D. Association of Kikuchi–Fujimoto's disease with SLE. Rheumatology (Oxford). 2008;47:553-4.

Hutchinson CB, Wang E. Kikuchi-Fujimoto disease. Arch Pathol Lab Med. 2010;134:289-93.

Kwon SY, Kim TY, Kim, Lee KY, Lee NJ, Seol HY. CT findings in Kikuchi disease: analysis of 96 cases. Am J Neuroradiol. 2004;25(6):1099-102.

Douglas M, Bradbury R, Kannangara S, Mitchell D. Arthritis as an unusual manifestation of Kikuchi-Fujimoto disease. Rheumatology. 2003;42(8):1010-2.

Rezai K, Kuchipudi S, Chundi V, Ariga R, Loew J, Sha BE. Kikuchi-Fujimoto disease: hydroxychloroquine as a treatment. Clin Infectious Diseases. 2004;39(12):e124-6.

Kucukardali Y, Solmazgul E, Kunter E, Oncul O, Yildirim S, Kaplan M. Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin Rheumatol. 2007;26(1):50-4.