The incidence of osteoporosis and vertebral fracture in women with postmenopausal type 2 diabetes mellitus and predisposing factors of vertebral fractures

Tugcan Alp Kirkizlar; Mehmet Burak Aktuglu

doi:10.18203/2349-3933.ijam20213702

Authors

Tugcan Alp Kirkizlar Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Istanbul, Turkey http://orcid.org/0000-0002-1361-6213
Mehmet Burak Aktuglu Department of Internal Medicine, Haseki Training and Research Hospital, Istanbul, Turkey http://orcid.org/0000-0002-6379-3883

DOI:

https://doi.org/10.18203/2349-3933.ijam20213702

Keywords:

Menopause, Type 2 DM, Fracture, Vertebrae

Abstract

Background: Type 2 diabetes mellitus (DM) has an increased fracture risk due to loss of bone quality and tendency to falling. The aim of the study was to analyze the incidence of osteoporosis and vertebral fractures (VF) in postmenopausal women with type 2 DM and to define the risk factors of VF in terms of clinical, metabolic characteristics and diabetes related microvascular complications.

Methods: The 42 postmenopausal patients with type 2 DM were included to the study in Haseki Training and Research Hospital outpatient clinics.

Results: Osteoporosis with regard to lumbar spine (LS) and femur neck (FN) was 8.4%, 19.4%, respectively. Vertebral fracture ratio was 31%. There was no statistical significance between vertebral fracture and osteoporosis. In logistic regression analysis, longer postmenopausal period, higher postprandial blood glucose (PBG), presence of peripheral neuropathy was found associated with vertebral fracture (p=0.04, 0.04, and 0.05, respectively).

Conclusions: In this study we suggest to consider the length of postmenopausal period, PBG and peripheral neuropathy for assessing the risk of VF.

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Author Biographies

Tugcan Alp Kirkizlar, Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Istanbul, Turkey

Assistant Profesor, Hematology Department

Mehmet Burak Aktuglu, Department of Internal Medicine, Haseki Training and Research Hospital, Istanbul, Turkey

Internal Medicine Department

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