Published: 2021-07-23

Clinico-epidemiological profile of COVID-19 among health care workers from a tertiary care hospital

Anuradha Tolpadi, Abhijeet Mane, Jitendra Oswal, Sujata Rege, Meera Modak, Sujitkumar Landge, Asmita Gade, Reshma Tanpure


Background: Coronavirus disease 2019 (COVID-19) is a global health issue. Healthcare workers (HCWs) are especially vulnerable to infection by SARS-CoV-2. The present study was conducted to determine the proportion of HCWs infected with COVID 19 in a tertiary care centre with emphasis on the epidemiological and clinical aspect

Methods: HCWs (symptomatic and asymptomatic contacts) who tested positive for COVID-19 by SARS-CoV-RTPCR or COVID-19 rapid antigen test were included in the study. Demographic and clinical data of the infected HCWs was obtained through a detailed telephonic interview with structured questionnaire.

Results: Out of total 921 HCWs tested for COVID-19 (SARS-CoV-2 RT-PCR and Rapid antigen test), 323 (35%) HCWs were positive. Proportion of COVID-19 positive HCWs among all HCWs was 13.67% (323/2362). Most COVID-19 positive HCWs (88%) were symptomatic. Majority of infected HCWs (62.23%) were between the age group of 21-30 years. Nurses were the most predominantly affected among various categories of HCWs (42.41%). Fever was the most common presenting symptom, seen in 160 (49.50%) HCWs. Comorbidities were found in 28 (8.66%) of infected HCWs. Majority of HCWs (86%) suffered from mild infection.

Conclusions: HCWs, especially nurses, face a high risk of COVID-19 infection while providing care for suspected or confirmed COVID-19 patients. It is important to characterize the epidemiological and clinical profile of HCWs regarding COVID-19 for formulation of prevention and management strategies.


COVID-19 infection, SARS-CoV-2, Infection control, Health care worker

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Zhu N, Zhang D, Wang W, Li X, Yang B. A novel corona virus from patients with pneumonia in China. 2019. N Engl J Med. 2020;382(8):727-33.

World Health Organization. WHO Director–General’s opening remarks at the media briefing on COVID-19-11March 2020. Available at: -media-briefing -on covid-19---11–march-2020. Accessed on March 17, 2020.

Wikipedia. Coronavirus Pandemic in India, 2020. Available at: php?title=2020coronaviruspandem_India&oldid=950858032. Accessed on 1 June 2021.

Li Q, Guan X, Wu P, Wang X, Zhou L. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N Eng j Med. 2020;382(13):1199-207.

Dave M, Vijayvargiya R, Poswal L, Bedi V, Sharma M. Study of COVID -19 seroprevalence among healthcare workers at dedicated COVID hospital in southern Rajasthan. Indian J Clin practice. 2020;31(2):107-11.

Wang D, Hu C, Zhu F, Liu X, Zhang J. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323:1061-9.

Lou Y, Trevathan E, Qian Z, Li Y, Li J.Asymptomatic SARS-CoV-2 infection in household contacts of a healthcare provider, Wuhan, China. Emerg Infect Dis. 2020;26:8.

Wee LE, Sim XYJ, Conceicao EP, Aung MK, Goh JQ et al. Containment of COVID -19 cases among healthcare workers: the role of surveillance, early detection, and outbreak management, Infect Control Hosp Epidemiol. 2020;11:1-7.

Gracia S, Lopez MJ, Vicente A, Abascal P. SARS-CoV-2 infection among healthcare workers in a hospital in Madrid, Spain. J Hospital infection. 2020;106:357-63.

WHO. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Available at: https:// clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected. Accessed on 10 Jan 2020.

Al Maskari Z, Al Blush A, Khamis F, Tai A, Sami I. Characteristics of healthcare workers infected with COVID-19: A cross sectional observational study. Int J Infectious Diseases. 2021;102:32-6.

Behera V, Srivastava PK, Jayaramchandran J, Ray S, Hande V, Mathai S. COVID-19 in healthcare workers: A review of existing literature. J Mar Med Soc. 2020;22:S36-45.

Wang X, Liu W, Zhao J, Lu Y, Yu C et al. Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China. J Hospital Infect. 2020;105:399-403.

Zheng L, Wang X, Zhou C, Liu Q, Li S et al. Analysis of the infection status of healthcare workers in Wuhan during the COVID-19 outbreak: A cross-sectional study. 2020;71(16):2109-13.

Fusco FM, Pisaturo M, Iodice V, Bellopede R, Tambaro O et al. COVID-19 among healthcare workers in a specialist infectious disease setting in Naples, southern Italy: results of a cross –sectional surveillance study. J Hospital Infection. 2020;105;296-600

Banerjee A, Mukherjee K, Bhattacharjee D, Garai D, Chakraborty R. Status of Health-care workers in relation to COVID-19 infection: A retrospective study in a level 4 COVID hospital in eastern India. JAPI. 2020.

Chen T, Li G, Liu H, Wan W, Zheng H, Chen C. Clinical characteristics of 132 healthcare worker cases with COVID‐19: A retrospective study from a single center in Wuhan, China. J Med Virol. 2021;93:1631‐8.

Marjolein FQ, Kluytmans V, Anton G. Prevelence and clinical presentation of health care workers with symptoms of Coronavirus Disease 2019 in 2 Dutch Hospitals during an early phase of the pandemic. JAMA. 2020:e209673.

Bandyopadhay S, Baticulon RE, Kadhum M. Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review. BMJ Global Health. 2020;5:e003097.