Serum procalcitonin as a biomarker of sepsis

Authors

  • Nyamnyei Konyak Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004
  • Linda Marangmei Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004
  • Medo M. Kuotsu Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004
  • Laishram Chittaranjan Singh Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004
  • L. Shaini Devi Department of Biochemistry, Regional Institute of Medical Sciences, Imphal-795004
  • S. Bhagyabati Devi Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004,

DOI:

https://doi.org/10.18203/2349-3933.ijam20213704

Keywords:

Procalcitonin, Sepsis, SIRS, Positive culture

Abstract

Background: The overlap of clinical presentation between sepsis and SIRS has presented diagnostic difficulty in these two close common scenarios. Blood culture remains the gold standard for detection of specific micro-organism, the non-availability of culture report early and difficulty in culture of many organisms is a challenge in differentiation of sepsis from its mimickers. Keeping this background, a simple tool is needed to guide sepsis management while awaiting the culture report. Therefore, the present study is conducted to determine the procalcitonin level in the setting suspicious of sepsis and to differentiate it from SIRS. The objective of the study was to determine Serum procalcitonin level as a biomarker of early diagnosis of sepsis and also to differentiate sepsis from severe inflammatory response syndrome.

Methods: Cross sectional study on 79 patients aged above 18 years with suspected sepsis admitted in medicine ward. Serum procalcitonin levels were measured and analysed to look for any association with sepsis.

Results: Culture was positive in 41 patients and 38 patients were procalcitonin positive. The sensitivity, specificity, positive predictive value and negative predictive values of serum procalcitonin were found as 96.68%, 94.74%, 95% and 92.30% respectively.

Conclusions: There was a significant association between serum procalcitonin and culture positivity. Procalcitonin levels was found to have high sensitivity and high positive predictive value which may aid in the early diagnosis and guide initiation of anti-microbial therapy in sepsis.

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Author Biographies

Nyamnyei Konyak, Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004

Post Graduate Trainee, Department of Medicine, Regional Institute of Medical Sciences, Imphal

Linda Marangmei, Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004

Assistant Professor, Department of  Medicine, Regional Institute of Medical Sciences, Imphal-795004

Medo M. Kuotsu, Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004

Post Graduate Trainee, Department of  Medicine, Regional Institute of Medical Sciences, Imphal-795004

Laishram Chittaranjan Singh, Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004

Post Graduate Trainee, Department of  Medicine, Regional Institute of Medical Sciences, Imphal-795004

L. Shaini Devi, Department of Biochemistry, Regional Institute of Medical Sciences, Imphal-795004

Professor, Department of  Biochemistry, Regional Institute of Medical Sciences, Imphal-795004

S. Bhagyabati Devi, Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004,

Professor (Retd.), Department of  Medicine, Regional Institute of Medical Sciences, Imphal-795004,

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Published

2021-09-22

How to Cite

Konyak, N., Marangmei, L., Kuotsu, M. M., Singh, L. C., Devi, L. S., & Devi, S. B. (2021). Serum procalcitonin as a biomarker of sepsis. International Journal of Advances in Medicine, 8(10), 1494–1498. https://doi.org/10.18203/2349-3933.ijam20213704

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Original Research Articles