Published: 2016-12-24

Comparison between the effects of premedication with and placebo on the patient’s anxiety, coronary angiography complications and the procedure time

Behzad Babapour, Bijan Zamani, Mehdi Ataei, Mina Golalizadeh


Background: Cardiovascular disease is the main cause of death in the world. One of the methods for diagnosis of coronary artery diseases is angiography which may entail several complications in patients like anxiety which is one of the most common complications. Drug therapy in most of centers is often used to soothe patients and avoid complications of angiography. This study aimed at investigating the effects of two current methods of premedication for coronary angiography and placebo on the level of patients' anxiety, complication of angiography, and its duration.

Methods: In this clinical trial, 150 patients under coronary angiography selected through convenience sampling were randomly assigned into a control and two premedication groups, i.e., 50 patients in each group. In premedication groups, patients received drugs including diazepam+promethazin and hydrocortisone or midazolam and in the control group, the patients received only routine nursing cares. Data collection tools were a checklist about demographic information, access site, hemodynamic parameter (systolic and diastolic blood pressure, pulse rate, respiratory rate) which was completed1 hour prior to and during angiography, and spielberger anxiety questionnaire and complications related to angiography. The data were analyzed by statistical methods in SPSS.19.

Results: There was no significant difference between the control and the premedication groups regarding hemodynamic parameters, the patients' anxiety level, the complications and the procedure time.

Conclusions: According to findings, we suggest premeditations not to be used before angiography as far as possible (except for specific cases), in order to prevent patients from undergoing inappropriate drug therapy along with an invasive diagnostic method. 


Angiography, Anxiety, Coronary artery, Complication, Premedication

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