DOI: http://dx.doi.org/10.18203/2349-3933.ijam20213202

Prevalence of subclinical hypothyroidism in metabolic syndrome: our experience from Karnataka

Praveen R. Badri, Tanveer Ahmed, Anant Arunrao Takalkar

Abstract


Background: Metabolic syndrome is a collection of factors which can increase the risk of heart disease, stroke and diabetes. Subclinical hypothyroidism is a state of mild thyroid failure. There are few factors which increase the risk for developing subclinical hypothyroidism such as female gender, advanced age and greater dietary iodine intake. Subclinical hypothyroidism as it is more common than overt hypothyroidism. Objectives were to study prevalence of subclinical hypothyroidism in patients of metabolic syndrome and its association with demographic and clinical parameters.

Methods: This cross-sectional observational study was conducted on patients attending General Medicine OPD and in-patients admitted at Navodaya Medical College and Hospital, Raichur including 103 cases of metabolic syndrome. The data was analyzed using statistical package for the social sciences (SPSS) 24.0 version.

Results: Prevalence of subclinical hypothyroidism in our study was 30.1%. Majority were from 41-50 years age group i.e., 9 (29%) and majority were females i.e., 17 (54.8%). We did not find any association between Subclinical hypothyroidism and gender (p>0.05). Prevalence of overweight in our study among SCH was 35.5% compared to 18.1% of normal patients. Elevated levels of TG were observed in 64 i.e., 62.1%, elevated TC 23.3%, elevated levels of LDL in 30.1% patients.

Conclusions: Prevalence of subclinical hypothyroidism in our study was 30.1%. Majority were from 41-50 years age group i.e., 29% and majority were females i.e., 17 (54.8%). We did not find any association between subclinical hypothyroidism and body mass index (BMI) in our study.


Keywords


Metabolic syndrome, Subclinical hypothyroidism, Clinical profile

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References


Tehrani FR, Tohidi M, Dovom MR, Azizi F. A population-based study on the association of thyroid status with components of the metabolic syndrome. J Diabetes Metab. 2011;2:156-62.

Misra A, Khurana L. The metabolic syndrome in South Asians: epidemiology, determinants, and prevention. Metab Syndr Relat Disord. 2009;7:497-514.

Sharma SK, Ghimire A, Radhakrishnan J, Thapa L, Shrestha NR, Paudel N, et al Prevalence of hypertension, obesity, diabetes, and metabolic syndrome in Nepal. Int J Hypertens. 2011;821-971.

Misra A, Misra R, Wijesuriya M, Banerjee D. The metabolic syndrome in South Asians: continuing escalation & possible solutions. Indian J Med Res. 2007;125:345-54.

Wong ND, Sciammarella MG, Polk D, Gallagher A, Miranda-Peats L, Whitcomb B et al The metabolic syndrome, diabetes, and subclinical atherosclerosis assessed by coronary calcium. J Am Coll Cardiol. 2003;41:1547-53.

Alejandro R. Ayala,Mark D. Danese, Paul W. Ladenson, When to treat mild hypothyroidism. Endocrinology and metabolism clinics of North America. 2000;29:399-415.

Jameson JL, Mandel SJ, Weetman AP. Disorders of the thyroid gland 19th ed Vol 2 Harrison’s principles of Internal medicine. McGraw-Hill Education. 2015.

Brent GA, Weetman AP. Hypothyroidism and thyroiditis 13th ed William’s textbook of Endocrinology. Elsevier, Inc. 2016;439.

Cooper DS, Subclinical hypothyroidism. JAMA. 1987;258;246-7.

Arem R, Escalante D. Subclinical hypothyroidism: epidemiology, diagnosis, and significance. Adv Intern Med. 1996;41:213-50.

Cooper DS. Subclinical thyroid disease: a clinician’s perspective. Ann Intern Med. 1998;129:135-8.

Ayala AR, Danese MD, Ladenson PW. When to treat mild hypothyroidism. Endocrinol Metab Clin North Am. 2000;29:399-415

Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA; The spectrum of thyroid disease in a community: the Whickham survey. Clinical endocrinology. 1977;7(6):481-93.

An American Heart Association/National Heart, Lung and Blood Institute Scientific Statement. Diagnosis and management of the metabolic syndrome. Circulation. 2005;112:2735-52.

Aljabri KS, Alnasser IM, Bokhari SA, Alshareef MA, Khan PM, Mallisho AM, et al. The Prevalence of Subclinical Hypothyroidism in Patients with Metabolic Syndrome in Saudi Community based Hospital: A Retrospective Single Centre Study. EC Diabetes and Metabolic Research. 2019;44-9.

Meher LK, Raveendranathan SK, Kota SK, Sarangi J, Jali SN. Prevalence of hypothyroidism in patients with metabolic syndrome. Thyroid Research and Practice. 2013;10(2):60.

Shantha GP, Kumar AA, Jeyachandran V, Rajamanickam D, Rajkumar K, Salim S, Subramanian KK, Natesan S. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India. Thyroid research. 2009;2(1):2.

Shrestha S, Das BK, Baral N, Chandra L. Association of metabolic syndrome and its components with thyroid dysfunction in females. Int J Diab Dev Ctries. 2007;27(1):25.

Wang JY, Wang CY, Pei D, Lai CC, Chen YL, Wu CZ, Chang YL, Hsu CH, Pei C, Tang SH. Association between thyroid function and metabolic syndrome in elderly subjects. Journal of the American Geriatrics Society. 2010;58(8):1613-4.

Tehrani FR, Tohidi M, Dovom MR, Azizi F. A population-based study on the association of thyroid status with components of the metabolic syndrome. J Diabetes Metab. 2011;2(8):156-68.

Khatiwada S, Sah SK, Rajendra KC, Baral N, Lamsal M. Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome. Clinical Diabetes and Endocrinology. 2016;2(1):3.

Gyawali P, Takanche JS, Shrestha RK, Bhattarai P, Khanal K, Risal P, Koju R. Pattern of thyroid dysfunction in patients with metabolic syndrome and its relationship with components of metabolic syndrome. Diabetes & metabolism journal. 2015;39(1):66-73.

Jayakumar RV. Hypothyroidism and metabolic syndrome. Thyroid Res Pract. 2013;10:1-2.

Agarwal G, Sudhakar MK, Singh M, Senthil N, Rajendran A. The prevalence of thyroid dysfunction among South Indian women with metabolic syndrome. J Clin Diagn Res. 2011;5(2):213-6.

Uzunlulu M, Yorulmaz E, Oguz A. Prevalence of subclinical hypothyroidism in patients with metabolic syndrome. Endocrine journal. 2007;54(1):71-6.

Meng Z, Liu M, Zhang Q, Liu L, Song K, Tan J, Jia Q, Zhang G, Wang R, He Y, Ren X. Gender and age impacts on the association between thyroid function and metabolic syndrome in Chinese. Medicine. 2015;94(50).

Singh BM, Goswami B, Mallika V. Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital. Indian journal of clinical Biochemistry. 2010;25(2):141-5.

Bermudez V, Salazar J, Añez R, Rojas M, Estrella V, Ordoñez M, Chacín M, Hernández JD, Arias V, Cabrera M, Cano-Ponce C. Metabolic Syndrome and Subclinical Hypothyroidism: A Type 2 Diabetes-Dependent Association. Journal of thyroid research. 2018.

Senthil N, Sneha T, Santhosh P, Sujatha S. A study of prevalence of thyroid dysfunction in patients with metabolic syndrome. Int J Res Med Sci. 2015;3:3171-6.