DOI: http://dx.doi.org/10.18203/2349-3933.ijam20170116

Insulin resistance and its associated comorbidities in young individuals: a HOMA study

Irfan Ahamed H. B., Bilal Bin Abdullah, Mohammed Ismail, Syed Aman Jagirdar

Abstract


Background: The strongest relationship between insulin resistance and cardiovascular risk factors is observed in middle-aged persons rather than in older individuals. Hence it is important to evaluate the young high risk individuals for insulin resistance and to study its significant co-morbidities. Therefore, the present study was designed to evaluate the high risk individuals for insulin resistance and co-morbidities in young individuals.

Methods: The body mass index and the waist-hip ratio of all the participants were measured. A 5 ml of fasting venous blood was collected from each patient and was used for the estimation of fasting blood glucose level, lipid profile, fasting insulin level and glycated hemoglobin using commercially available kit according to the manufacturer’s guidelines. Subjects’ full filling inclusion criteria and preliminary tests for insulin resistance are further evaluated with HOMA. The data obtained was represented as Mean±S.D and was analyzed for statistical significance using chi-square test and correlation of HOMA with study variables were performed using Pearson correlation test using SPSS Version 20. P - value less than 0.05 was considered the level of significance.

Results: In the present study we found that, non- diabetic group patients are having strong association with hypertension and insulin resistance. When the study variables in the recruited subjects were correlated with HOMA using Pearson correlation, showed a significant correlation with fasting blood sugar, glycated hemoglobin and hypertension in diabetic patients. In non-diabetic subjects fasting blood sugar and glycated hemoglobin was not correlated significantly. But, hypertension showed a significant correlation.

Conclusions: Insulin resistance was strongly associated with co-morbidities like hypertension, obesity,   hyperlipidemia, hyperuricemia. High incidence and prevalence of insulin resistance was also seen in non-diabetic individuals.


Keywords


HOMA, Hypertension, Hyperlipidemia, Hyperuricemia, Obesity

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References


Moadab MH, Kelishadi R, Hashemipour M, Amini M, Poursafa P. The prevalence of impaired fasting glucose and type 2 diabetes in a population-based sample of overweight/obese children in the middle east. Pediatr Diabetes. 2010;11(2):101-6.

Sarti C, Gallagher J. The metabolic syndrome: prevalence, CHD risk and treatment. J Diabetes Complications. 2006;20(2):121-32.

Marchal LC, Arslanian S, Cutfield W, Sinaiko A, Druet C, Marcovecchio ML, et al. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab. 2010;95(12):5189-98.

Nielsen BH. General characteristics of the insulin resistance syndrome: prevalence and heritability. European Group for the study of Insulin Resistance (EGIR). Drugs. 1999;58(1):7-10.

Ferrannini E, Natali A, Bell P, Perin PC, Lalic N, Mingrone G. Insulin resistance and hypersecretion in obesity. J Clin Invest. 1997;100(5):1166-73.

Chittaranjan S, Yajnik MD. The insulin resistance epidemic in India: fetal origins, later lifestyle, or both? Nutr Rev. 2001;59(1):1-9.

Ferrannini E, Buzzigoli G, Bonadona R. Insulin resistance in essential hypertension. N Engl Med. 1987;317(6):350-7.

Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities: the role of insulin resistance and sympathetic adrenal system. N Engl J Med. 1996;334:374-81.

Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, et al. Prevalence of insulin resistance in metabolic disorders. Diabetes. 1998;47:1643-9.

Mathur SK, Chandra P, Mishra S, Ajmera P. Type-2 diabetes related intermediate phenotypic traits in north Indian diabetics. Indian J Clinic Biochem. 2007;22(2):70-3.

Mcgarry JD. What if minkowski had been ageusic? an alternative angle on diabetes. Science. 1992;258:766-70.

Mckeigue PM, Miller GJ, Marmot MG. Coronary heart disease in south asians overseas: a review. J Clin Epidemiol. 1989;42:597-09.

Laakso M, Connor BE. Asymptomatic hyperglycemia is associated with lipid and lipoprotein changes favoring atherosclerosis. Arteriosclerosis. 1989;9:665-72.

Garg A, Helderman JH, Koffler M. Relationship between lipoprotein levels and in vivo insulin action in normal young white men. Metabolism. 1988;37:982-7.

Evans DJ, Hoffmann RG, Kalkhoff RK. Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metabolism. 1984;33:68-75.

Krotkiewski M, Bjorntorp P, Sjostrom L. Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest. 1983;72:1150-62.

Sung KC, Kim BJ, Kim BS, Kang JH, Lee MH, Park JR, et al. In normoglycemic Koreans, insulin resistance and adipocity are independently correlated with high blood pressure. Circulation J. 2004;68:898-902.

Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, et al. Prevlence of insulin resistance in metabolic disorders. Diabetes. 1998;47:1643-9.

Berkowitz D. Gout, hyperlipidemia and diabetes interrelationships. JAMA. 1966;197:77-80.