Insulin resistance and its associated comorbidities in young individuals: a HOMA study
Keywords:HOMA, Hypertension, Hyperlipidemia, Hyperuricemia, Obesity
Background: The strongest relationship between insulin resistance and cardiovascular risk factors is observed in middle-aged persons rather than in older individuals. Hence it is important to evaluate the young high risk individuals for insulin resistance and to study its significant co-morbidities. Therefore, the present study was designed to evaluate the high risk individuals for insulin resistance and co-morbidities in young individuals.
Methods: The body mass index and the waist-hip ratio of all the participants were measured. A 5 ml of fasting venous blood was collected from each patient and was used for the estimation of fasting blood glucose level, lipid profile, fasting insulin level and glycated hemoglobin using commercially available kit according to the manufacturer’s guidelines. Subjects’ full filling inclusion criteria and preliminary tests for insulin resistance are further evaluated with HOMA. The data obtained was represented as Mean±S.D and was analyzed for statistical significance using chi-square test and correlation of HOMA with study variables were performed using Pearson correlation test using SPSS Version 20. P - value less than 0.05 was considered the level of significance.
Results: In the present study we found that, non- diabetic group patients are having strong association with hypertension and insulin resistance. When the study variables in the recruited subjects were correlated with HOMA using Pearson correlation, showed a significant correlation with fasting blood sugar, glycated hemoglobin and hypertension in diabetic patients. In non-diabetic subjects fasting blood sugar and glycated hemoglobin was not correlated significantly. But, hypertension showed a significant correlation.
Conclusions: Insulin resistance was strongly associated with co-morbidities like hypertension, obesity, hyperlipidemia, hyperuricemia. High incidence and prevalence of insulin resistance was also seen in non-diabetic individuals.
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